Verapamil upregulates sensitivity of human colon and breast cancer cells to LAK-cytotoxicity in vitro

Pierpaolo Correale, Pierosandro Tagliaferri, Luigi Celio, Geppino Genua, Stefania Montagnani, Angelo Raffaele Bianco

Research output: Contribution to journalArticle

Abstract

Pretreatment of human colon cancer LoVo-H cells and human breast cancer ZR-75 1A cells with low doses of verapamil, a Ca2+ channel blocker, for 48 h has a slight growth stimulatory effect and substantially increases cell sensitivity to lymphokine-activated killer (LAK) mediated cytotoxicity in the standard 51Cr release assay. The role of intracellular Ca2+ levels in determining verapamil effect is demonstrated by cytochemical evidence of intracellular Ca2+ lowering in verapamil-treated cells and by the reversal by the Ca2+ ionophore A-23187 of verapamil-induced sensitivity to LAK-mediated cytotoxicity.

Original languageEnglish
Pages (from-to)1393-1395
Number of pages3
JournalEuropean Journal of Cancer and Clinical Oncology
Volume27
Issue number11
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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