Verrucous-keratotic melanoma

R. Betti, R. Vergani, C. Pazzini, P. Martino, C. Crosti

Research output: Contribution to journalArticlepeer-review


Verrucous-keratotic melanoma is a variant of melanoma that may be confused with benign lesions. We report a case of a 58-year-old man with a verrucous-keratotic lesion on his left leg. The lesion resulted a verrucous melanoma level IV of Clark, 10.35 mm in thickness according to Breslow. Verrucous-keratotic melanomas are rarely mentioned today. They do not seem to have a sex and site predilection and they are clinically characterized by keratotic, exophytic and greyish surface. They have a tough, fleshy and not friable consistency. The main clinical differential diagnoses are with seborrheic keratosis and benign nevi. Histologically most of verrucous-keratotic melanomas resemble to the superficial spreading and acral lentiginous types of melanomas with verrucous surface. The prognosis of the verrucous-keratotic melanomas do not seem to be significantly different from other melanomas, but a long term follow-up is required for assess their true biologic behaviour.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalInternational Journal of Medicine, Biology and the Environment
Issue number2
Publication statusPublished - 1999


  • Differential diagnosis
  • Seborrheic keratosis
  • Verrucous-keratotic melanoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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