Versatility of the endoplasmic reticulum protein folding factory

Eelco Van Anken, Ineke Braakman

Research output: Contribution to journalArticlepeer-review


The endoplasmic reticulum (ER) is dedicated to import, folding and assembly of all proteins that travel along or reside in the secretory pathway of eukaryotic cells. Folding in the ER is special. For instance, newly synthesized proteins are N-glycosylated and by default form disulfide bonds in the ER, but not elsewhere in the cell. In this review, we discuss which features distinguish the ER as an efficient folding factory, how the ER monitors its output and how it disposes of folding failures.

Original languageEnglish
Pages (from-to)191-228
Number of pages38
JournalCritical Reviews in Biochemistry and Molecular Biology
Issue number4
Publication statusPublished - Jul 2005


  • BiP
  • Calnexin
  • Chaperones
  • EDEM
  • ERAD
  • PDI

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry


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