Vertebral Artery Diameter and Flow: Nature or Nurture

Adam Domonkos Tarnoki, Bence Fejer, David Laszlo Tarnoki, Levente Littvay, Pierleone Lucatelli, Carlo Cirelli, Fabrizio Fanelli, Beatrice Sacconi, Corrado Fagnani, Emanuela Medda, Filippo Farina, Giorgio Meneghetti, Tamas Horvath, Giacomo Pucci, Giuseppe Schillaci, Maria Antonietta Stazi, Claudio Baracchini

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: In contrast with the carotid arteries, the vertebral arteries (VAs) show considerable variation in length, caliber, and vessel course. This study investigated whether the variation in diameter and flow characteristics of the VAs might be inherited. METHODS: A total of 172 Italian twins from Padua, Perugia, and Terni (54 monozygotic, 32 dizygotic) recruited from the Italian Twin Registry underwent B-mode and pulsed-wave Doppler ultrasound assessment of their VAs. VA diameters, peak systolic velocity (PSV) and end diastolic velocity (EDV) were assessed at the level of a horizontal V2 segment. Univariate quantitative genetic modeling was performed. RESULTS: Fourteen percent of the sample had VA hypoplasia. Within pair correlation in monozygotic twins was higher than in dizygotics (.552 vs.229) for VA diameter. Age- and sex-adjusted genetic effect, under the most parsimonious model, accounted for 54.7% (95% CI: 42.2-69.1%) of the variance of VA diameter, and unshared environmental effect for 45.3% (95% CI: 30.9-57.8%). No heritability was found for the PSV of VA, but shared (34.1%; 95% CI: 16.7-53.7%) and unshared (65.9%; 95% CI: 45.9-83.1%) environmental factors determined the variance. EDV of VA is moderately genetically influenced (42.4%; 95% CI: 16.1-64.9%) and also determined by the unshared environment (57.6%; 95% CI: 34.7-83.7%). CONCLUSIONS: The diameter of the VAs is moderately genetically determined. Different factors influence the PSV and EDV of VAs, which may highlight the complex hemodynamic background of VA flow and help to understand the vertebral flow anomalies found by ultrasound.

Original languageEnglish
Pages (from-to)499-504
Number of pages6
JournalJournal of Neuroimaging
Volume27
Issue number5
DOIs
Publication statusPublished - Sep 1 2017

Fingerprint

Vertebral Artery
Doppler Ultrasonography
Monozygotic Twins
Carotid Arteries
Registries
Hemodynamics

Keywords

  • Doppler
  • flow
  • genetics
  • hypoplasia
  • velocity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Tarnoki, A. D., Fejer, B., Tarnoki, D. L., Littvay, L., Lucatelli, P., Cirelli, C., ... Baracchini, C. (2017). Vertebral Artery Diameter and Flow: Nature or Nurture. Journal of Neuroimaging, 27(5), 499-504. https://doi.org/10.1111/jon.12434

Vertebral Artery Diameter and Flow : Nature or Nurture. / Tarnoki, Adam Domonkos; Fejer, Bence; Tarnoki, David Laszlo; Littvay, Levente; Lucatelli, Pierleone; Cirelli, Carlo; Fanelli, Fabrizio; Sacconi, Beatrice; Fagnani, Corrado; Medda, Emanuela; Farina, Filippo; Meneghetti, Giorgio; Horvath, Tamas; Pucci, Giacomo; Schillaci, Giuseppe; Stazi, Maria Antonietta; Baracchini, Claudio.

In: Journal of Neuroimaging, Vol. 27, No. 5, 01.09.2017, p. 499-504.

Research output: Contribution to journalArticle

Tarnoki, AD, Fejer, B, Tarnoki, DL, Littvay, L, Lucatelli, P, Cirelli, C, Fanelli, F, Sacconi, B, Fagnani, C, Medda, E, Farina, F, Meneghetti, G, Horvath, T, Pucci, G, Schillaci, G, Stazi, MA & Baracchini, C 2017, 'Vertebral Artery Diameter and Flow: Nature or Nurture', Journal of Neuroimaging, vol. 27, no. 5, pp. 499-504. https://doi.org/10.1111/jon.12434
Tarnoki AD, Fejer B, Tarnoki DL, Littvay L, Lucatelli P, Cirelli C et al. Vertebral Artery Diameter and Flow: Nature or Nurture. Journal of Neuroimaging. 2017 Sep 1;27(5):499-504. https://doi.org/10.1111/jon.12434
Tarnoki, Adam Domonkos ; Fejer, Bence ; Tarnoki, David Laszlo ; Littvay, Levente ; Lucatelli, Pierleone ; Cirelli, Carlo ; Fanelli, Fabrizio ; Sacconi, Beatrice ; Fagnani, Corrado ; Medda, Emanuela ; Farina, Filippo ; Meneghetti, Giorgio ; Horvath, Tamas ; Pucci, Giacomo ; Schillaci, Giuseppe ; Stazi, Maria Antonietta ; Baracchini, Claudio. / Vertebral Artery Diameter and Flow : Nature or Nurture. In: Journal of Neuroimaging. 2017 ; Vol. 27, No. 5. pp. 499-504.
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AU - Littvay, Levente

AU - Lucatelli, Pierleone

AU - Cirelli, Carlo

AU - Fanelli, Fabrizio

AU - Sacconi, Beatrice

AU - Fagnani, Corrado

AU - Medda, Emanuela

AU - Farina, Filippo

AU - Meneghetti, Giorgio

AU - Horvath, Tamas

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