Vertebral fractures in patients with chronic obstructive pulmonary disease: The EOLO Study

R. Nuti, P. Siviero, S. Maggi, G. Guglielmi, C. Caffarelli, G. Crepaldi, S. Gonnelli

Research output: Contribution to journalArticlepeer-review

Abstract

Summary: This study aimed to evaluate the prevalence of vertebral fractures to investigate the determinants of vertebral fracture risk in patients with COPD. The risk of vertebral fractures is strictly related to the severity of the disease. The use of glucocorticoids and the presence of low values of quantitative ultrasound (QUS) may represent additional risk factors. Introduction: Chronic obstructive pulmonary disease (COPD) appears to be associated with osteoporosis. Our study aimed to evaluate the prevalence of vertebral fractures and to investigate the main determinants of vertebral fracture risk in patients with COPD. Methods: In 3,030 ambulatory COPD patients (1,778 men and 1,262 women) aged 50 years or over, we evaluated: COPD severity, presence of vertebral fractures on lateral chest X-ray and bone status by using a quantitative ultrasound device. Results: In men there was a strong association between COPD severity and fractures (p∈

Original languageEnglish
Pages (from-to)989-998
Number of pages10
JournalOsteoporosis International
Volume20
Issue number6
DOIs
Publication statusPublished - Jun 2009

Keywords

  • COPD
  • Glucocorticoids
  • Quantitative ultrasound
  • Vertebral fractures

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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