Vertical transmission of hepatitis C virus in a cohort of 2,447 HIV-seronegative pregnant women: A 24-month prospective study

Oronzo Ceci, Marcella Margiotta, Fiorino Marello, Ruggiero Francavilla, Pasquale Loizzi, Antonio Francavilla, Angela Mautone, Luigi Impedovo, Enzo Ierardi, Maria Mastroianni, Stefano Bettocchi, Luigi Selvaggi

Research output: Contribution to journalArticle

Abstract

Background: Mother to infant transmission of hepatitis C virus (HCV) has been extensively studied in mothers with human immunodeficiency virus (HIV) infection, whereas fewer data are available on the vertical HCV transmission in HIV-negative women. Methods: Between January 1995 and June 1997, 78 consecutive HCV-positive/HIV-negative women with their offspring entered this prospective study aimed to define the prevalence of and risk factors for HCV vertical transmission. Risk factors for HCV were carefully sought, and HCV viral load and genotype were determined in all positive mothers. The infants were tested for alanine aminotransferase (ALT) and HCV-RNA at birth and at 4, 8, 12, 18, and 24 months of age. Results: Eight of 60 (13.3%) infants born to HCV-RNA positive mothers acquired HCV infection, but only 2 (3,3%) were still infected by the end of follow-up. Infants' genotypes matched that of the mothers. ALT levels were in the normal range in all study subjects throughout the follow-up. High maternal viral load (P <0.05), possession of HCV risk factors (P <0.004), and history of blood transfusion (P <0.05) were associated with increased risk of HCV vertical transmission. Conclusions: This long-term prospective study shows that, although vertical transmission from HIV-negative mothers occurs in 13% of cases, there is a high rate of spontaneous viral clearance (75%). High maternal viral load and mothers belonging to HCV risk categories were the only variables predictive of the vertical transmission.

Original languageEnglish
Pages (from-to)570-575
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume33
Issue number5
DOIs
Publication statusPublished - 2001

Fingerprint

Human immunodeficiency virus 2
HIV-2
Hepatitis C virus
pregnant women
prospective studies
Hepacivirus
Pregnant Women
Prospective Studies
Mothers
Human immunodeficiency virus
viral load
Viral Load
HIV
risk factors
Virus Diseases
Alanine Transaminase
alanine transaminase
Genotype
RNA
blood transfusion

Keywords

  • HCV RNA titer
  • HCV/HIV co-infection
  • Hepatitis C virus
  • Spontaneous viral clearance
  • Vertical transmission

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Vertical transmission of hepatitis C virus in a cohort of 2,447 HIV-seronegative pregnant women : A 24-month prospective study. / Ceci, Oronzo; Margiotta, Marcella; Marello, Fiorino; Francavilla, Ruggiero; Loizzi, Pasquale; Francavilla, Antonio; Mautone, Angela; Impedovo, Luigi; Ierardi, Enzo; Mastroianni, Maria; Bettocchi, Stefano; Selvaggi, Luigi.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 33, No. 5, 2001, p. 570-575.

Research output: Contribution to journalArticle

Ceci, O, Margiotta, M, Marello, F, Francavilla, R, Loizzi, P, Francavilla, A, Mautone, A, Impedovo, L, Ierardi, E, Mastroianni, M, Bettocchi, S & Selvaggi, L 2001, 'Vertical transmission of hepatitis C virus in a cohort of 2,447 HIV-seronegative pregnant women: A 24-month prospective study', Journal of Pediatric Gastroenterology and Nutrition, vol. 33, no. 5, pp. 570-575. https://doi.org/10.1097/00005176-200111000-00011
Ceci, Oronzo ; Margiotta, Marcella ; Marello, Fiorino ; Francavilla, Ruggiero ; Loizzi, Pasquale ; Francavilla, Antonio ; Mautone, Angela ; Impedovo, Luigi ; Ierardi, Enzo ; Mastroianni, Maria ; Bettocchi, Stefano ; Selvaggi, Luigi. / Vertical transmission of hepatitis C virus in a cohort of 2,447 HIV-seronegative pregnant women : A 24-month prospective study. In: Journal of Pediatric Gastroenterology and Nutrition. 2001 ; Vol. 33, No. 5. pp. 570-575.
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abstract = "Background: Mother to infant transmission of hepatitis C virus (HCV) has been extensively studied in mothers with human immunodeficiency virus (HIV) infection, whereas fewer data are available on the vertical HCV transmission in HIV-negative women. Methods: Between January 1995 and June 1997, 78 consecutive HCV-positive/HIV-negative women with their offspring entered this prospective study aimed to define the prevalence of and risk factors for HCV vertical transmission. Risk factors for HCV were carefully sought, and HCV viral load and genotype were determined in all positive mothers. The infants were tested for alanine aminotransferase (ALT) and HCV-RNA at birth and at 4, 8, 12, 18, and 24 months of age. Results: Eight of 60 (13.3{\%}) infants born to HCV-RNA positive mothers acquired HCV infection, but only 2 (3,3{\%}) were still infected by the end of follow-up. Infants' genotypes matched that of the mothers. ALT levels were in the normal range in all study subjects throughout the follow-up. High maternal viral load (P <0.05), possession of HCV risk factors (P <0.004), and history of blood transfusion (P <0.05) were associated with increased risk of HCV vertical transmission. Conclusions: This long-term prospective study shows that, although vertical transmission from HIV-negative mothers occurs in 13{\%} of cases, there is a high rate of spontaneous viral clearance (75{\%}). High maternal viral load and mothers belonging to HCV risk categories were the only variables predictive of the vertical transmission.",
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T1 - Vertical transmission of hepatitis C virus in a cohort of 2,447 HIV-seronegative pregnant women

T2 - A 24-month prospective study

AU - Ceci, Oronzo

AU - Margiotta, Marcella

AU - Marello, Fiorino

AU - Francavilla, Ruggiero

AU - Loizzi, Pasquale

AU - Francavilla, Antonio

AU - Mautone, Angela

AU - Impedovo, Luigi

AU - Ierardi, Enzo

AU - Mastroianni, Maria

AU - Bettocchi, Stefano

AU - Selvaggi, Luigi

PY - 2001

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N2 - Background: Mother to infant transmission of hepatitis C virus (HCV) has been extensively studied in mothers with human immunodeficiency virus (HIV) infection, whereas fewer data are available on the vertical HCV transmission in HIV-negative women. Methods: Between January 1995 and June 1997, 78 consecutive HCV-positive/HIV-negative women with their offspring entered this prospective study aimed to define the prevalence of and risk factors for HCV vertical transmission. Risk factors for HCV were carefully sought, and HCV viral load and genotype were determined in all positive mothers. The infants were tested for alanine aminotransferase (ALT) and HCV-RNA at birth and at 4, 8, 12, 18, and 24 months of age. Results: Eight of 60 (13.3%) infants born to HCV-RNA positive mothers acquired HCV infection, but only 2 (3,3%) were still infected by the end of follow-up. Infants' genotypes matched that of the mothers. ALT levels were in the normal range in all study subjects throughout the follow-up. High maternal viral load (P <0.05), possession of HCV risk factors (P <0.004), and history of blood transfusion (P <0.05) were associated with increased risk of HCV vertical transmission. Conclusions: This long-term prospective study shows that, although vertical transmission from HIV-negative mothers occurs in 13% of cases, there is a high rate of spontaneous viral clearance (75%). High maternal viral load and mothers belonging to HCV risk categories were the only variables predictive of the vertical transmission.

AB - Background: Mother to infant transmission of hepatitis C virus (HCV) has been extensively studied in mothers with human immunodeficiency virus (HIV) infection, whereas fewer data are available on the vertical HCV transmission in HIV-negative women. Methods: Between January 1995 and June 1997, 78 consecutive HCV-positive/HIV-negative women with their offspring entered this prospective study aimed to define the prevalence of and risk factors for HCV vertical transmission. Risk factors for HCV were carefully sought, and HCV viral load and genotype were determined in all positive mothers. The infants were tested for alanine aminotransferase (ALT) and HCV-RNA at birth and at 4, 8, 12, 18, and 24 months of age. Results: Eight of 60 (13.3%) infants born to HCV-RNA positive mothers acquired HCV infection, but only 2 (3,3%) were still infected by the end of follow-up. Infants' genotypes matched that of the mothers. ALT levels were in the normal range in all study subjects throughout the follow-up. High maternal viral load (P <0.05), possession of HCV risk factors (P <0.004), and history of blood transfusion (P <0.05) were associated with increased risk of HCV vertical transmission. Conclusions: This long-term prospective study shows that, although vertical transmission from HIV-negative mothers occurs in 13% of cases, there is a high rate of spontaneous viral clearance (75%). High maternal viral load and mothers belonging to HCV risk categories were the only variables predictive of the vertical transmission.

KW - HCV RNA titer

KW - HCV/HIV co-infection

KW - Hepatitis C virus

KW - Spontaneous viral clearance

KW - Vertical transmission

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