Very late activation-3 integrin is the dominant β1-integrin on the glomerular capillary wall

An immunofluorescence study in nephrotic syndrome

A. Baraldi, L. Furci, G. Zambruno, E. Rubbiani, G. Annessi, E. Lusvarghi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The expression of α2; α3; α5; α6-subunits of the β1 [very late activation (VLA)] integrin family was studied in kidney specimens using an immunofluorescent technique. 6 specimens from normal kidney were compared with 10 specimens from patients affected by various glomerulopathies [minimal change nephropathy (MCN), membranous nephropathy (MN) and systemic lupus erythematosus nephritis (SLEN)]. On normal glomeruli, α3 was the dominant integrin, being mainly present on podocytes and showing a linear fluorescent pattern codistributed with laminin. In MCN and SLEN, α3 presented a normal pattern. In MN, α3 revealed a trabecular picture on thickened glomerular basement membranes. Moreover, in stage-III MN, a segmental loss of α3-integrin was detected. In our opinion, VLA-3 may offer an interesting approach to the study of the relationships between podocytes and their substrate.

Original languageEnglish
Pages (from-to)382-388
Number of pages7
JournalNephron
Volume62
Issue number4
Publication statusPublished - 1992

Fingerprint

Membranous Glomerulonephritis
Nephrotic Syndrome
Integrins
Fluorescent Antibody Technique
Lipoid Nephrosis
Podocytes
Lupus Nephritis
Systemic Lupus Erythematosus
Kidney
Glomerular Basement Membrane
Laminin

Keywords

  • β (very late activation) integrins
  • Glomeruli
  • Membranous nephropathy
  • Minimal change nephropathy
  • Very late activation-3 integrin

ASJC Scopus subject areas

  • Nephrology

Cite this

Very late activation-3 integrin is the dominant β1-integrin on the glomerular capillary wall : An immunofluorescence study in nephrotic syndrome. / Baraldi, A.; Furci, L.; Zambruno, G.; Rubbiani, E.; Annessi, G.; Lusvarghi, E.

In: Nephron, Vol. 62, No. 4, 1992, p. 382-388.

Research output: Contribution to journalArticle

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AU - Furci, L.

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AU - Rubbiani, E.

AU - Annessi, G.

AU - Lusvarghi, E.

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AB - The expression of α2; α3; α5; α6-subunits of the β1 [very late activation (VLA)] integrin family was studied in kidney specimens using an immunofluorescent technique. 6 specimens from normal kidney were compared with 10 specimens from patients affected by various glomerulopathies [minimal change nephropathy (MCN), membranous nephropathy (MN) and systemic lupus erythematosus nephritis (SLEN)]. On normal glomeruli, α3 was the dominant integrin, being mainly present on podocytes and showing a linear fluorescent pattern codistributed with laminin. In MCN and SLEN, α3 presented a normal pattern. In MN, α3 revealed a trabecular picture on thickened glomerular basement membranes. Moreover, in stage-III MN, a segmental loss of α3-integrin was detected. In our opinion, VLA-3 may offer an interesting approach to the study of the relationships between podocytes and their substrate.

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