Very light physical activity amount in FTO genetically predisposed obese individuals

Giuseppe Labruna, Maurizio Marra, Carmela Nardelli, Annamaria Mancini, Pasqualina Buono, Lucia Sacchetti, Fabrizio Pasanisi

Research output: Contribution to journalArticlepeer-review


Purpose: Fat mass and obesity-related (FTO) rs9939609 polymorphism has a role in body mass index (BMI) increase and in predisposing to metabolic syndrome (MetS). Our aim was to investigate if a very light physical activity could counteract weight gain and MetS in obese subjects bearing the rs9939609 FTO polymorphism from Southern Italy. Methods: Data of fitness components, anthropometry, clinical-biochemical parameters and FTO polymorphism in 78 unrelated morbid obese subjects from Southern Italy (15–30 years) were examined. Physical activity energy expenditure was monitored by a SenseWear Pro 3 Armband for 24 h/day for 2 consecutive weekdays in all enrolled individuals. Results: Sedentary obese subjects had higher waist circumference (124.8 vs 117.9 cm, P < 0.05), BMI (43.4 vs 37.7 kg/m2, P < 0.0001) and fat mass (49.2 vs 44.5%, P < 0.0001) compared to lightly active ones. Further, lightly active obese subjects bearing the rs9939609 FTO minor allele had a lower BMI than polymorphic sedentary ones (37.1 vs 45.3 kg/m2, respectively, P < 0.01), and did not differ in metabolic syndrome presence. Conclusion: Our results suggest that a very light amount of physical exercise is associated with a lower BMI in obese subjects bearing the minor allele of the rs9939609 FTO polymorphism.

Original languageEnglish
Pages (from-to)689-697
Number of pages9
JournalSport Sciences for Health
Issue number3
Publication statusPublished - Dec 1 2019


  • BMI
  • FTO polymorphism
  • Metabolic syndrome
  • Obesity
  • Very light intensity exercise

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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