TY - JOUR
T1 - Vesicoureteral reflux
T2 - Current trends in diagnosis, screening, and treatment
AU - Routh, Jonathan C.
AU - Bogaert, Guy A.
AU - Kaefer, Martin
AU - Manzoni, Gianantonio
AU - Park, John M.
AU - Retik, Alan B.
AU - Rushton, H. Gil
AU - Snodgrass, Warren T.
AU - Wilcox, Duncan T.
PY - 2012/4
Y1 - 2012/4
N2 - Context: Vesicoureteral reflux (VUR) is present in approximately 1% of children in North America and Europe and is associated with an increased risk of pyelonephritis and renal scarring. Despite its prevalence and potential morbidity, however, many aspects of VUR management are controversial. Objective: Review the evidence surrounding current controversies in VUR diagnosis, screening, and treatment. Evidence acquisition: A systematic review was performed of Medline, Embase, Prospero, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, clinicaltrials.gov, and the most recent guidelines of relevant medical specialty organizations. Evidence synthesis: We objectively assessed and summarized the published data, focusing on recent areas of controversy relating to VUR screening, diagnosis, and treatment. Conclusions: The evidence base for many current management patterns in VUR is limited. Areas that could significantly benefit from additional future research include improved identification of children who are at risk for VUR-related renal morbidity, improved stratification tools for determining which children would benefit most from which VUR treatment option, and improved reporting of long-term outcomes of VUR treatments.
AB - Context: Vesicoureteral reflux (VUR) is present in approximately 1% of children in North America and Europe and is associated with an increased risk of pyelonephritis and renal scarring. Despite its prevalence and potential morbidity, however, many aspects of VUR management are controversial. Objective: Review the evidence surrounding current controversies in VUR diagnosis, screening, and treatment. Evidence acquisition: A systematic review was performed of Medline, Embase, Prospero, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, clinicaltrials.gov, and the most recent guidelines of relevant medical specialty organizations. Evidence synthesis: We objectively assessed and summarized the published data, focusing on recent areas of controversy relating to VUR screening, diagnosis, and treatment. Conclusions: The evidence base for many current management patterns in VUR is limited. Areas that could significantly benefit from additional future research include improved identification of children who are at risk for VUR-related renal morbidity, improved stratification tools for determining which children would benefit most from which VUR treatment option, and improved reporting of long-term outcomes of VUR treatments.
KW - Diagnosis
KW - Pediatrics
KW - Screening
KW - Treatment
KW - Vesicoureteral reflux
UR - http://www.scopus.com/inward/record.url?scp=84862823799&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862823799&partnerID=8YFLogxK
U2 - 10.1016/j.eururo.2012.01.002
DO - 10.1016/j.eururo.2012.01.002
M3 - Article
C2 - 22264440
AN - SCOPUS:84862823799
VL - 61
SP - 773
EP - 782
JO - European Urology
JF - European Urology
SN - 0302-2838
IS - 4
ER -