Vesicular transmitter release from astrocytes

Vedrana Montana, Erik B. Malarkey, Claudia Verderio, Michela Matteoli, Vladimir Parpura

Research output: Contribution to journalArticlepeer-review

Abstract

Astrocytes can release a variety of transmitters, including glutamate and ATP, in response to stimuli that induce increases in intracellular Ca 2+ levels. This release occurs via a regulated, exocytotic pathway. As evidence of this, astrocytes express protein components of the vesicular secretory apparatus, including synaptobrevin 2, syntaxin, and SNAP-23. Additionally, astrocytes possess vesicular organelles, the essential morphological elements required for regulated Ca2+-dependent transmitter release. The location of specific exocytotic sites on these cells, however, remains to be unequivocally determined.

Original languageEnglish
Pages (from-to)700-715
Number of pages16
JournalGLIA
Volume54
Issue number7
DOIs
Publication statusPublished - Nov 15 2006

Keywords

  • ATP
  • Ca excitability
  • Exocytosis
  • Glutamate
  • SNARE proteins
  • Synapse
  • Vesicle

ASJC Scopus subject areas

  • Immunology

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