Vesicular transmitter release from astrocytes

Vedrana Montana; Erik B. Malarkey; Claudia Verderio; Michela Matteoli; Vladimir Parpura

doi:10.1002/glia.20367

Vesicular transmitter release from astrocytes

Vedrana Montana, Erik B. Malarkey, Claudia Verderio, Michela Matteoli, Vladimir Parpura

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Astrocytes can release a variety of transmitters, including glutamate and ATP, in response to stimuli that induce increases in intracellular Ca ²⁺ levels. This release occurs via a regulated, exocytotic pathway. As evidence of this, astrocytes express protein components of the vesicular secretory apparatus, including synaptobrevin 2, syntaxin, and SNAP-23. Additionally, astrocytes possess vesicular organelles, the essential morphological elements required for regulated Ca²⁺-dependent transmitter release. The location of specific exocytotic sites on these cells, however, remains to be unequivocally determined.

Original language	English
Pages (from-to)	700-715
Number of pages	16
Journal	GLIA
Volume	54
Issue number	7
DOIs	https://doi.org/10.1002/glia.20367
Publication status	Published - Nov 15 2006

Keywords

ATP
Ca excitability
Exocytosis
Glutamate
SNARE proteins
Synapse
Vesicle

ASJC Scopus subject areas

Immunology

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AU - Montana, Vedrana

AU - Malarkey, Erik B.

AU - Verderio, Claudia

AU - Matteoli, Michela

AU - Parpura, Vladimir

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N2 - Astrocytes can release a variety of transmitters, including glutamate and ATP, in response to stimuli that induce increases in intracellular Ca 2+ levels. This release occurs via a regulated, exocytotic pathway. As evidence of this, astrocytes express protein components of the vesicular secretory apparatus, including synaptobrevin 2, syntaxin, and SNAP-23. Additionally, astrocytes possess vesicular organelles, the essential morphological elements required for regulated Ca2+-dependent transmitter release. The location of specific exocytotic sites on these cells, however, remains to be unequivocally determined.

AB - Astrocytes can release a variety of transmitters, including glutamate and ATP, in response to stimuli that induce increases in intracellular Ca 2+ levels. This release occurs via a regulated, exocytotic pathway. As evidence of this, astrocytes express protein components of the vesicular secretory apparatus, including synaptobrevin 2, syntaxin, and SNAP-23. Additionally, astrocytes possess vesicular organelles, the essential morphological elements required for regulated Ca2+-dependent transmitter release. The location of specific exocytotic sites on these cells, however, remains to be unequivocally determined.

KW - ATP

KW - Ca excitability

KW - Exocytosis

KW - Glutamate

KW - SNARE proteins

KW - Synapse

KW - Vesicle

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Vesicular transmitter release from astrocytes

Abstract

Keywords

ASJC Scopus subject areas

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