Vessel density, retinal thickness, and choriocapillaris vascular flow in myopic eyes on OCT angiography

Paolo Milani, Giovanni Montesano, Luca Rossetti, Fulvio Bergamini, Alfredo Pece

Research output: Contribution to journalArticlepeer-review


Purpose: To investigate foveal avascular zone area, macular vascular density, choroidal thickness, and outer retina and choriocapillaris flow in myopic eyes by OCT angiography. Methods: Automated macular maps and flow calculations were retrospectively evaluated in 42 myopic and in 40 control eyes. Results: Myopic eyes presented lower whole superficial vessel density (46.4 ± 4.9 vs. 51.6 ± 3.6%, P < 0.0001) and higher flow area in the outer retina (1.3 ± 0.2 vs. 1.1 ± 0.3 mm2, P = 0.0012). Between the myopic and non-myopic eyes, no significant differences could be detected in the choriocapillaris perfusion area (1.9 ± 0.07 vs. 1.9 ± 0.05 mm2, respectively; P = 0.55) and in the foveal avascular zone area (0.23 ± 0.1 vs. 0.26 ± 0.1 mm2, respectively; P = 0.12). The spherical correction positively correlated with superficial vessel density and negatively correlated with outer retina perfusion (P ≤ 0.0021). The superficial vessel density and the local retinal thickness positively correlated at all macular locations (P < 0.005), especially in the foveal region (P < 0.0001). Conclusions: Eyes with high myopia present reduced superficial vascular density and increased outer retina flow. Superficial vascular density and retinal thickness appear to be significantly correlated.

Original languageEnglish
Pages (from-to)1419-1427
Number of pages9
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number8
Publication statusPublished - Aug 1 2018


  • Choriocapillaris
  • Myopia
  • OCT angiography
  • Outer retina
  • Vessel density

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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