Abstract
Purpose: To investigate foveal avascular zone area, macular vascular density, choroidal thickness, and outer retina and choriocapillaris flow in myopic eyes by OCT angiography. Methods: Automated macular maps and flow calculations were retrospectively evaluated in 42 myopic and in 40 control eyes. Results: Myopic eyes presented lower whole superficial vessel density (46.4 ± 4.9 vs. 51.6 ± 3.6%, P < 0.0001) and higher flow area in the outer retina (1.3 ± 0.2 vs. 1.1 ± 0.3 mm2, P = 0.0012). Between the myopic and non-myopic eyes, no significant differences could be detected in the choriocapillaris perfusion area (1.9 ± 0.07 vs. 1.9 ± 0.05 mm2, respectively; P = 0.55) and in the foveal avascular zone area (0.23 ± 0.1 vs. 0.26 ± 0.1 mm2, respectively; P = 0.12). The spherical correction positively correlated with superficial vessel density and negatively correlated with outer retina perfusion (P ≤ 0.0021). The superficial vessel density and the local retinal thickness positively correlated at all macular locations (P < 0.005), especially in the foveal region (P < 0.0001). Conclusions: Eyes with high myopia present reduced superficial vascular density and increased outer retina flow. Superficial vascular density and retinal thickness appear to be significantly correlated.
| Original language | English |
|---|---|
| Pages (from-to) | 1419-1427 |
| Number of pages | 9 |
| Journal | Graefe's Archive for Clinical and Experimental Ophthalmology |
| Volume | 256 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1 2018 |
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Keywords
- Choriocapillaris
- Myopia
- OCT angiography
- Outer retina
- Vessel density
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Vessel density, retinal thickness, and choriocapillaris vascular flow in myopic eyes on OCT angiography. / Milani, Paolo; Montesano, Giovanni; Rossetti, Luca; Bergamini, Fulvio; Pece, Alfredo.
In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 256, No. 8, 01.08.2018, p. 1419-1427.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vessel density, retinal thickness, and choriocapillaris vascular flow in myopic eyes on OCT angiography
AU - Milani, Paolo
AU - Montesano, Giovanni
AU - Rossetti, Luca
AU - Bergamini, Fulvio
AU - Pece, Alfredo
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Purpose: To investigate foveal avascular zone area, macular vascular density, choroidal thickness, and outer retina and choriocapillaris flow in myopic eyes by OCT angiography. Methods: Automated macular maps and flow calculations were retrospectively evaluated in 42 myopic and in 40 control eyes. Results: Myopic eyes presented lower whole superficial vessel density (46.4 ± 4.9 vs. 51.6 ± 3.6%, P < 0.0001) and higher flow area in the outer retina (1.3 ± 0.2 vs. 1.1 ± 0.3 mm2, P = 0.0012). Between the myopic and non-myopic eyes, no significant differences could be detected in the choriocapillaris perfusion area (1.9 ± 0.07 vs. 1.9 ± 0.05 mm2, respectively; P = 0.55) and in the foveal avascular zone area (0.23 ± 0.1 vs. 0.26 ± 0.1 mm2, respectively; P = 0.12). The spherical correction positively correlated with superficial vessel density and negatively correlated with outer retina perfusion (P ≤ 0.0021). The superficial vessel density and the local retinal thickness positively correlated at all macular locations (P < 0.005), especially in the foveal region (P < 0.0001). Conclusions: Eyes with high myopia present reduced superficial vascular density and increased outer retina flow. Superficial vascular density and retinal thickness appear to be significantly correlated.
AB - Purpose: To investigate foveal avascular zone area, macular vascular density, choroidal thickness, and outer retina and choriocapillaris flow in myopic eyes by OCT angiography. Methods: Automated macular maps and flow calculations were retrospectively evaluated in 42 myopic and in 40 control eyes. Results: Myopic eyes presented lower whole superficial vessel density (46.4 ± 4.9 vs. 51.6 ± 3.6%, P < 0.0001) and higher flow area in the outer retina (1.3 ± 0.2 vs. 1.1 ± 0.3 mm2, P = 0.0012). Between the myopic and non-myopic eyes, no significant differences could be detected in the choriocapillaris perfusion area (1.9 ± 0.07 vs. 1.9 ± 0.05 mm2, respectively; P = 0.55) and in the foveal avascular zone area (0.23 ± 0.1 vs. 0.26 ± 0.1 mm2, respectively; P = 0.12). The spherical correction positively correlated with superficial vessel density and negatively correlated with outer retina perfusion (P ≤ 0.0021). The superficial vessel density and the local retinal thickness positively correlated at all macular locations (P < 0.005), especially in the foveal region (P < 0.0001). Conclusions: Eyes with high myopia present reduced superficial vascular density and increased outer retina flow. Superficial vascular density and retinal thickness appear to be significantly correlated.
KW - Choriocapillaris
KW - Myopia
KW - OCT angiography
KW - Outer retina
KW - Vessel density
UR - http://www.scopus.com/inward/record.url?scp=85048042381&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048042381&partnerID=8YFLogxK
U2 - 10.1007/s00417-018-4012-y
DO - 10.1007/s00417-018-4012-y
M3 - Article
C2 - 29876731
AN - SCOPUS:85048042381
VL - 256
SP - 1419
EP - 1427
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
SN - 0721-832X
IS - 8
ER -