Vessel density, retinal thickness, and choriocapillaris vascular flow in myopic eyes on OCT angiography

Paolo Milani, Giovanni Montesano, Luca Rossetti, Fulvio Bergamini, Alfredo Pece

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: To investigate foveal avascular zone area, macular vascular density, choroidal thickness, and outer retina and choriocapillaris flow in myopic eyes by OCT angiography. Methods: Automated macular maps and flow calculations were retrospectively evaluated in 42 myopic and in 40 control eyes. Results: Myopic eyes presented lower whole superficial vessel density (46.4 ± 4.9 vs. 51.6 ± 3.6%, P < 0.0001) and higher flow area in the outer retina (1.3 ± 0.2 vs. 1.1 ± 0.3 mm2, P = 0.0012). Between the myopic and non-myopic eyes, no significant differences could be detected in the choriocapillaris perfusion area (1.9 ± 0.07 vs. 1.9 ± 0.05 mm2, respectively; P = 0.55) and in the foveal avascular zone area (0.23 ± 0.1 vs. 0.26 ± 0.1 mm2, respectively; P = 0.12). The spherical correction positively correlated with superficial vessel density and negatively correlated with outer retina perfusion (P ≤ 0.0021). The superficial vessel density and the local retinal thickness positively correlated at all macular locations (P < 0.005), especially in the foveal region (P < 0.0001). Conclusions: Eyes with high myopia present reduced superficial vascular density and increased outer retina flow. Superficial vascular density and retinal thickness appear to be significantly correlated.

Original languageEnglish
Pages (from-to)1419-1427
Number of pages9
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume256
Issue number8
DOIs
Publication statusPublished - Aug 1 2018

Fingerprint

Retinal Vessels
Blood Vessels
Angiography
Retina
Perfusion
Myopia

Keywords

  • Choriocapillaris
  • Myopia
  • OCT angiography
  • Outer retina
  • Vessel density

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

@article{46adffb479044273a558699c5580c2ae,
title = "Vessel density, retinal thickness, and choriocapillaris vascular flow in myopic eyes on OCT angiography",
abstract = "Purpose: To investigate foveal avascular zone area, macular vascular density, choroidal thickness, and outer retina and choriocapillaris flow in myopic eyes by OCT angiography. Methods: Automated macular maps and flow calculations were retrospectively evaluated in 42 myopic and in 40 control eyes. Results: Myopic eyes presented lower whole superficial vessel density (46.4 ± 4.9 vs. 51.6 ± 3.6{\%}, P < 0.0001) and higher flow area in the outer retina (1.3 ± 0.2 vs. 1.1 ± 0.3 mm2, P = 0.0012). Between the myopic and non-myopic eyes, no significant differences could be detected in the choriocapillaris perfusion area (1.9 ± 0.07 vs. 1.9 ± 0.05 mm2, respectively; P = 0.55) and in the foveal avascular zone area (0.23 ± 0.1 vs. 0.26 ± 0.1 mm2, respectively; P = 0.12). The spherical correction positively correlated with superficial vessel density and negatively correlated with outer retina perfusion (P ≤ 0.0021). The superficial vessel density and the local retinal thickness positively correlated at all macular locations (P < 0.005), especially in the foveal region (P < 0.0001). Conclusions: Eyes with high myopia present reduced superficial vascular density and increased outer retina flow. Superficial vascular density and retinal thickness appear to be significantly correlated.",
keywords = "Choriocapillaris, Myopia, OCT angiography, Outer retina, Vessel density",
author = "Paolo Milani and Giovanni Montesano and Luca Rossetti and Fulvio Bergamini and Alfredo Pece",
year = "2018",
month = "8",
day = "1",
doi = "10.1007/s00417-018-4012-y",
language = "English",
volume = "256",
pages = "1419--1427",
journal = "Graefe's Archive for Clinical and Experimental Ophthalmology",
issn = "0721-832X",
publisher = "Springer Verlag",
number = "8",

}

TY - JOUR

T1 - Vessel density, retinal thickness, and choriocapillaris vascular flow in myopic eyes on OCT angiography

AU - Milani, Paolo

AU - Montesano, Giovanni

AU - Rossetti, Luca

AU - Bergamini, Fulvio

AU - Pece, Alfredo

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Purpose: To investigate foveal avascular zone area, macular vascular density, choroidal thickness, and outer retina and choriocapillaris flow in myopic eyes by OCT angiography. Methods: Automated macular maps and flow calculations were retrospectively evaluated in 42 myopic and in 40 control eyes. Results: Myopic eyes presented lower whole superficial vessel density (46.4 ± 4.9 vs. 51.6 ± 3.6%, P < 0.0001) and higher flow area in the outer retina (1.3 ± 0.2 vs. 1.1 ± 0.3 mm2, P = 0.0012). Between the myopic and non-myopic eyes, no significant differences could be detected in the choriocapillaris perfusion area (1.9 ± 0.07 vs. 1.9 ± 0.05 mm2, respectively; P = 0.55) and in the foveal avascular zone area (0.23 ± 0.1 vs. 0.26 ± 0.1 mm2, respectively; P = 0.12). The spherical correction positively correlated with superficial vessel density and negatively correlated with outer retina perfusion (P ≤ 0.0021). The superficial vessel density and the local retinal thickness positively correlated at all macular locations (P < 0.005), especially in the foveal region (P < 0.0001). Conclusions: Eyes with high myopia present reduced superficial vascular density and increased outer retina flow. Superficial vascular density and retinal thickness appear to be significantly correlated.

AB - Purpose: To investigate foveal avascular zone area, macular vascular density, choroidal thickness, and outer retina and choriocapillaris flow in myopic eyes by OCT angiography. Methods: Automated macular maps and flow calculations were retrospectively evaluated in 42 myopic and in 40 control eyes. Results: Myopic eyes presented lower whole superficial vessel density (46.4 ± 4.9 vs. 51.6 ± 3.6%, P < 0.0001) and higher flow area in the outer retina (1.3 ± 0.2 vs. 1.1 ± 0.3 mm2, P = 0.0012). Between the myopic and non-myopic eyes, no significant differences could be detected in the choriocapillaris perfusion area (1.9 ± 0.07 vs. 1.9 ± 0.05 mm2, respectively; P = 0.55) and in the foveal avascular zone area (0.23 ± 0.1 vs. 0.26 ± 0.1 mm2, respectively; P = 0.12). The spherical correction positively correlated with superficial vessel density and negatively correlated with outer retina perfusion (P ≤ 0.0021). The superficial vessel density and the local retinal thickness positively correlated at all macular locations (P < 0.005), especially in the foveal region (P < 0.0001). Conclusions: Eyes with high myopia present reduced superficial vascular density and increased outer retina flow. Superficial vascular density and retinal thickness appear to be significantly correlated.

KW - Choriocapillaris

KW - Myopia

KW - OCT angiography

KW - Outer retina

KW - Vessel density

UR - http://www.scopus.com/inward/record.url?scp=85048042381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048042381&partnerID=8YFLogxK

U2 - 10.1007/s00417-018-4012-y

DO - 10.1007/s00417-018-4012-y

M3 - Article

C2 - 29876731

AN - SCOPUS:85048042381

VL - 256

SP - 1419

EP - 1427

JO - Graefe's Archive for Clinical and Experimental Ophthalmology

JF - Graefe's Archive for Clinical and Experimental Ophthalmology

SN - 0721-832X

IS - 8

ER -