Abstract
The aim of the present work was to examine the effects of postoperative treatments with agents active on dopaminergic system on vestibular recovery from the postural and ocular symptoms which follow a unilateral labyrinthectomy. Hemilabyrinthectomized guinea pigs were given a daily i.p. injection of bromocriptine (1 mg/kg) or sulpiride (10 mg/kg) or lisuride (0.1 mg/kg) or saline from post-operative days 1 to 21. Treatment with bromocriptine, a D2 agonist, accelerates compensation of postural and ocular symptoms. Conversely, treatment with sulpiride, a D2 antagonist, slows down the reachievement of symmetrical posture and stable ocular motility. Finally, the lisuride treatment, a drug active on D2 but also on other monoaminergic receptors, delays vestibular recovery so markedly to reach a "freezing" of vestibular deficits during drug treatment. These findings indicate that the already demonstrated role of dopamine in motor activity and learning can be extended to the learning processes required to recover from vestibular asymmetries.
| Original language | English |
|---|---|
| Pages (from-to) | 159-171 |
| Number of pages | 13 |
| Journal | Archives Italiennes de Biologie |
| Volume | 131 |
| Issue number | 2-3 |
| Publication status | Published - Apr 1993 |
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ASJC Scopus subject areas
- Medicine(all)
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Vestibular compensation is affected by treatment with dopamine active agents. / Petrosini, L.; Dell'Anna, M. E.
In: Archives Italiennes de Biologie, Vol. 131, No. 2-3, 04.1993, p. 159-171.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vestibular compensation is affected by treatment with dopamine active agents.
AU - Petrosini, L.
AU - Dell'Anna, M. E.
PY - 1993/4
Y1 - 1993/4
N2 - The aim of the present work was to examine the effects of postoperative treatments with agents active on dopaminergic system on vestibular recovery from the postural and ocular symptoms which follow a unilateral labyrinthectomy. Hemilabyrinthectomized guinea pigs were given a daily i.p. injection of bromocriptine (1 mg/kg) or sulpiride (10 mg/kg) or lisuride (0.1 mg/kg) or saline from post-operative days 1 to 21. Treatment with bromocriptine, a D2 agonist, accelerates compensation of postural and ocular symptoms. Conversely, treatment with sulpiride, a D2 antagonist, slows down the reachievement of symmetrical posture and stable ocular motility. Finally, the lisuride treatment, a drug active on D2 but also on other monoaminergic receptors, delays vestibular recovery so markedly to reach a "freezing" of vestibular deficits during drug treatment. These findings indicate that the already demonstrated role of dopamine in motor activity and learning can be extended to the learning processes required to recover from vestibular asymmetries.
AB - The aim of the present work was to examine the effects of postoperative treatments with agents active on dopaminergic system on vestibular recovery from the postural and ocular symptoms which follow a unilateral labyrinthectomy. Hemilabyrinthectomized guinea pigs were given a daily i.p. injection of bromocriptine (1 mg/kg) or sulpiride (10 mg/kg) or lisuride (0.1 mg/kg) or saline from post-operative days 1 to 21. Treatment with bromocriptine, a D2 agonist, accelerates compensation of postural and ocular symptoms. Conversely, treatment with sulpiride, a D2 antagonist, slows down the reachievement of symmetrical posture and stable ocular motility. Finally, the lisuride treatment, a drug active on D2 but also on other monoaminergic receptors, delays vestibular recovery so markedly to reach a "freezing" of vestibular deficits during drug treatment. These findings indicate that the already demonstrated role of dopamine in motor activity and learning can be extended to the learning processes required to recover from vestibular asymmetries.
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M3 - Article
C2 - 8101705
AN - SCOPUS:0027587744
VL - 131
SP - 159
EP - 171
JO - Archives Italiennes de Biologie
JF - Archives Italiennes de Biologie
SN - 0003-9829
IS - 2-3
ER -