Video assisted thoracoscopic extended thymectomy (VATET) in Myasthenia Gravis

101 patients followed-up to 2 years and comparison with transternal approach

R. Mantegazza, P. Confalonieri, C. Aniozzi, L. Novellino, M. T. Ferrè, M. Porta, G. Pezzuoli, F. Cornelio

Research output: Contribution to journalArticle

Abstract

Thymectomy without stemotomy was performed by bilateral VATET in 101 MG patients. The histological evaluation revealed a thymoma in 20.89? of cases, an hyperplastic thymus in 48.5% and an involuted thymus in 30.7%. Fifty-seven (56.4%) of our patients had a follow-up of at least 1 year; 30 (29.7%) patients up to 2 years. Comparison of tissue removed by VATET or standard transternal thymectomy showed significant differences in all cases (55.6 ±38.2 vs. 35.54 ±35 grams, p = 0.001) or in only those without thymoma (43.6 ±21.5 vs. 26.3 ±23.5 grams, p = 0.0001) (unpaired r-Test). In the VATET patients the clinical conditions were detected at the end of follow-up: remission, 23.3%; pharmacological remission, 41.7%; ocular, 6.7%: generalized, 23.3%; bulbar, 5% compared to 1.7, 30, 13.3, 45 and 10%, respectively, before thymectomy. No complication occured immediately after or later on in the follow-up. On the basis of these results VATET technique is proposed as a safe, reliable and even more radical thymectomy for MG treatment.

Original languageEnglish
Pages (from-to)22
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

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Thymectomy
Myasthenia Gravis
Thymoma
Thymus Gland
Pharmacology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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Video assisted thoracoscopic extended thymectomy (VATET) in Myasthenia Gravis : 101 patients followed-up to 2 years and comparison with transternal approach. / Mantegazza, R.; Confalonieri, P.; Aniozzi, C.; Novellino, L.; Ferrè, M. T.; Porta, M.; Pezzuoli, G.; Cornelio, F.

In: Italian Journal of Neurological Sciences, Vol. 18, No. 4, 1997, p. 22.

Research output: Contribution to journalArticle

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abstract = "Thymectomy without stemotomy was performed by bilateral VATET in 101 MG patients. The histological evaluation revealed a thymoma in 20.89? of cases, an hyperplastic thymus in 48.5{\%} and an involuted thymus in 30.7{\%}. Fifty-seven (56.4{\%}) of our patients had a follow-up of at least 1 year; 30 (29.7{\%}) patients up to 2 years. Comparison of tissue removed by VATET or standard transternal thymectomy showed significant differences in all cases (55.6 ±38.2 vs. 35.54 ±35 grams, p = 0.001) or in only those without thymoma (43.6 ±21.5 vs. 26.3 ±23.5 grams, p = 0.0001) (unpaired r-Test). In the VATET patients the clinical conditions were detected at the end of follow-up: remission, 23.3{\%}; pharmacological remission, 41.7{\%}; ocular, 6.7{\%}: generalized, 23.3{\%}; bulbar, 5{\%} compared to 1.7, 30, 13.3, 45 and 10{\%}, respectively, before thymectomy. No complication occured immediately after or later on in the follow-up. On the basis of these results VATET technique is proposed as a safe, reliable and even more radical thymectomy for MG treatment.",
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AU - Mantegazza, R.

AU - Confalonieri, P.

AU - Aniozzi, C.

AU - Novellino, L.

AU - Ferrè, M. T.

AU - Porta, M.

AU - Pezzuoli, G.

AU - Cornelio, F.

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N2 - Thymectomy without stemotomy was performed by bilateral VATET in 101 MG patients. The histological evaluation revealed a thymoma in 20.89? of cases, an hyperplastic thymus in 48.5% and an involuted thymus in 30.7%. Fifty-seven (56.4%) of our patients had a follow-up of at least 1 year; 30 (29.7%) patients up to 2 years. Comparison of tissue removed by VATET or standard transternal thymectomy showed significant differences in all cases (55.6 ±38.2 vs. 35.54 ±35 grams, p = 0.001) or in only those without thymoma (43.6 ±21.5 vs. 26.3 ±23.5 grams, p = 0.0001) (unpaired r-Test). In the VATET patients the clinical conditions were detected at the end of follow-up: remission, 23.3%; pharmacological remission, 41.7%; ocular, 6.7%: generalized, 23.3%; bulbar, 5% compared to 1.7, 30, 13.3, 45 and 10%, respectively, before thymectomy. No complication occured immediately after or later on in the follow-up. On the basis of these results VATET technique is proposed as a safe, reliable and even more radical thymectomy for MG treatment.

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