Videolaparoscopic cholecystectomy induces a hemostasis activation of lower grade than does open surgery

D. Prisco, A. R. De Gaudio, R. Carla, A. M. Gori, S. Fedi, A. P. Cella, G. F. Gensini, R. Abbate

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Background: Tissue injury after trauma and surgery may induce alterations in blood coagulation and fibrinolysis, and the hypercoagulable state observed after surgery can be associated with the risk of postoperative thromboembolic complications. Recently, videolaparoscopic (VLPS) cholecystectomy has been introduced, and its advantages over the open procedure seem related to the reduced surgical trauma. The aim of this study was to investigate hemostatic system alterations in patients who undergo open and VLPS cholecystectomy. Methods: Fibrinogen, prothrombin fragment F1+2, D- dimer, and plasminogen activator inhibitor type-1 (PAI-1) activity was determined in 10 patients who underwent open (group A) and 10 patients who underwent VLPS cholecystectomy (group B), respectively. Blood samples were obtained the day of surgery in the morning (B1), after anesthesia (A1), 1 hour after the start of surgery (S1), then 30 min (E.05) and 24 h (E.24) after the surgery. Results: No significant differences were observed in baseline values between groups A and B for the parameters investigated. At 24 h after surgery, fibrinogen increased significantly (p <0.05) in group A and also was significantly higher than in group B (p <0.05). In group A, a marked increase in F1+2 levels (p <0.01) was observed in all the samples, with the maximum values on the first day after surgery (3.7 nmol/l; 1.2-6.0 nmol/l), whereas in group B, a slight but significant increase in F1+2 levels (2.1 nmol/l; 1.1-3.9 nmol/l; p <0.01) was observed only 30 min after the end of surgery. In both groups A and B, D-dimer markedly increased after surgery, without statistical significant differences between the two groups at any time. The PAI-1 activity plasma levels remained in the normal range during and after surgery in both groups. Conclusions: These results indicate that VLPS surgery induces an activation of the clotting system that, although of low degree and short duration, can lead to a transient prothrombotic state.

Original languageEnglish
Pages (from-to)170-174
Number of pages5
JournalSurgical Endoscopy and Other Interventional Techniques
Volume14
Issue number2
DOIs
Publication statusPublished - Feb 2000

Fingerprint

Cholecystectomy
Hemostasis
Plasminogen Activator Inhibitor 1
Ambulatory Surgical Procedures
Fibrinogen
Wounds and Injuries
Blood Coagulation
Fibrinolysis
Hemostatics
Reference Values
Anesthesia

Keywords

  • Blood clotting activation
  • Open and videolaparoscopic cholecystectomy

ASJC Scopus subject areas

  • Surgery

Cite this

Videolaparoscopic cholecystectomy induces a hemostasis activation of lower grade than does open surgery. / Prisco, D.; De Gaudio, A. R.; Carla, R.; Gori, A. M.; Fedi, S.; Cella, A. P.; Gensini, G. F.; Abbate, R.

In: Surgical Endoscopy and Other Interventional Techniques, Vol. 14, No. 2, 02.2000, p. 170-174.

Research output: Contribution to journalArticle

Prisco, D, De Gaudio, AR, Carla, R, Gori, AM, Fedi, S, Cella, AP, Gensini, GF & Abbate, R 2000, 'Videolaparoscopic cholecystectomy induces a hemostasis activation of lower grade than does open surgery', Surgical Endoscopy and Other Interventional Techniques, vol. 14, no. 2, pp. 170-174. https://doi.org/10.1007/s004649900093
Prisco, D. ; De Gaudio, A. R. ; Carla, R. ; Gori, A. M. ; Fedi, S. ; Cella, A. P. ; Gensini, G. F. ; Abbate, R. / Videolaparoscopic cholecystectomy induces a hemostasis activation of lower grade than does open surgery. In: Surgical Endoscopy and Other Interventional Techniques. 2000 ; Vol. 14, No. 2. pp. 170-174.
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abstract = "Background: Tissue injury after trauma and surgery may induce alterations in blood coagulation and fibrinolysis, and the hypercoagulable state observed after surgery can be associated with the risk of postoperative thromboembolic complications. Recently, videolaparoscopic (VLPS) cholecystectomy has been introduced, and its advantages over the open procedure seem related to the reduced surgical trauma. The aim of this study was to investigate hemostatic system alterations in patients who undergo open and VLPS cholecystectomy. Methods: Fibrinogen, prothrombin fragment F1+2, D- dimer, and plasminogen activator inhibitor type-1 (PAI-1) activity was determined in 10 patients who underwent open (group A) and 10 patients who underwent VLPS cholecystectomy (group B), respectively. Blood samples were obtained the day of surgery in the morning (B1), after anesthesia (A1), 1 hour after the start of surgery (S1), then 30 min (E.05) and 24 h (E.24) after the surgery. Results: No significant differences were observed in baseline values between groups A and B for the parameters investigated. At 24 h after surgery, fibrinogen increased significantly (p <0.05) in group A and also was significantly higher than in group B (p <0.05). In group A, a marked increase in F1+2 levels (p <0.01) was observed in all the samples, with the maximum values on the first day after surgery (3.7 nmol/l; 1.2-6.0 nmol/l), whereas in group B, a slight but significant increase in F1+2 levels (2.1 nmol/l; 1.1-3.9 nmol/l; p <0.01) was observed only 30 min after the end of surgery. In both groups A and B, D-dimer markedly increased after surgery, without statistical significant differences between the two groups at any time. The PAI-1 activity plasma levels remained in the normal range during and after surgery in both groups. Conclusions: These results indicate that VLPS surgery induces an activation of the clotting system that, although of low degree and short duration, can lead to a transient prothrombotic state.",
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AU - Prisco, D.

AU - De Gaudio, A. R.

AU - Carla, R.

AU - Gori, A. M.

AU - Fedi, S.

AU - Cella, A. P.

AU - Gensini, G. F.

AU - Abbate, R.

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N2 - Background: Tissue injury after trauma and surgery may induce alterations in blood coagulation and fibrinolysis, and the hypercoagulable state observed after surgery can be associated with the risk of postoperative thromboembolic complications. Recently, videolaparoscopic (VLPS) cholecystectomy has been introduced, and its advantages over the open procedure seem related to the reduced surgical trauma. The aim of this study was to investigate hemostatic system alterations in patients who undergo open and VLPS cholecystectomy. Methods: Fibrinogen, prothrombin fragment F1+2, D- dimer, and plasminogen activator inhibitor type-1 (PAI-1) activity was determined in 10 patients who underwent open (group A) and 10 patients who underwent VLPS cholecystectomy (group B), respectively. Blood samples were obtained the day of surgery in the morning (B1), after anesthesia (A1), 1 hour after the start of surgery (S1), then 30 min (E.05) and 24 h (E.24) after the surgery. Results: No significant differences were observed in baseline values between groups A and B for the parameters investigated. At 24 h after surgery, fibrinogen increased significantly (p <0.05) in group A and also was significantly higher than in group B (p <0.05). In group A, a marked increase in F1+2 levels (p <0.01) was observed in all the samples, with the maximum values on the first day after surgery (3.7 nmol/l; 1.2-6.0 nmol/l), whereas in group B, a slight but significant increase in F1+2 levels (2.1 nmol/l; 1.1-3.9 nmol/l; p <0.01) was observed only 30 min after the end of surgery. In both groups A and B, D-dimer markedly increased after surgery, without statistical significant differences between the two groups at any time. The PAI-1 activity plasma levels remained in the normal range during and after surgery in both groups. Conclusions: These results indicate that VLPS surgery induces an activation of the clotting system that, although of low degree and short duration, can lead to a transient prothrombotic state.

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