Vigabatrin does not affect the intestinal absorption of phenytoin in rat duodeno-jejunal loops in situ

M. Tonini, G. Gatti, L. Manzo, G. Olibet, T. Coccini, E. Perucca

Research output: Contribution to journalArticle

Abstract

The antiepileptic drug vigabatrin (GVG) is known to decrease significantly the serum concentration of concurrently administered phenytoin (PHT) in epileptic patients. To assess a possible mechanism for this interaction, the effect of GVG on the intestinal absorption of PHT was investigated by means of circulation experiments in an in situ rat duodeno-jejunal loop. GVG did not affect the rate of disappearance of PHT from the loop perfusing medium, providing evidence against occurrence of GVG-induced impairment of PHT absorption.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalPharmacological Research
Volume26
Issue number2
DOIs
Publication statusPublished - 1992

Keywords

  • drug-drug interaction
  • intestinal absorption
  • phenytoin
  • rat intestine in situ
  • vigabatrin

ASJC Scopus subject areas

  • Pharmacology

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