Thirtytwo adult patients (16 females and 16 males, aged from 20 to 59 years) with refractory partial epilepsy entered a single blind study with Vigabatrin (VGB) as add on therapy. There were 19 drop outs. Thirteen patients continued the study, with a follow up of 6 years in 7 and of 3 years in 6. The number of seizures decreased by 100% in one patient, by 70 to 83.3% in four patients, by 50 to 64.28% in three patients and by 50% in five. The side effects were: drowsiness (13 pt), weight gain or appetite (12 pt), oedema (8 pt), sual disturbances (4 pt), appetite gain (3 pt), constipation (3 pt), ataxia (2 pt), delusional episode (1 pt), gastralgia (1 pt).
|Translated title of the contribution||Vigabatrin therapy: Tolerability in 32 adult patients|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1992|
ASJC Scopus subject areas
- Clinical Neurology