26 newly diagnosed and untreated patients with West Syndrome were randomly assigned to Gamma-Vinyl-GABA (GVG) (100-150 mg/kg/die) or ACTH Depot (0,1 ml/die) treatment. Spasms disappearance was observed in 6 patients (6/13 = 46%) treated with GVG (2 cryptogenic and 4 symptomatic) and in 10 patients (10/13 = 77%) treated with ACTH (6 cryptogenic and 7 symptomatic). GVG response occurred within 8 days. Treatment intolerance was observed in 2 cases, one treated with GVG and one treated with ACTH. After 3 months, side effects and relapses were more numerous in patients treated with ACTH. Thus, GVG can be suggested as first choice drug in infantile spasms treatment.
|Translated title of the contribution||Vigabatrin versus ACTH as first line therapy in West syndrome|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1994|
ASJC Scopus subject areas
- Clinical Neurology