VIGABATRIN VERSUS ACTH COME TERAPIA DI PRIMA SCELTA NELLA SINDROME DI WEST

Translated title of the contribution: Vigabatrin versus ACTH as first line therapy in West syndrome

F. Vigevano, M. R. Cilio, D. Claps, A. Faberi, A. Gisondi

Research output: Contribution to journalArticlepeer-review

Abstract

26 newly diagnosed and untreated patients with West Syndrome were randomly assigned to Gamma-Vinyl-GABA (GVG) (100-150 mg/kg/die) or ACTH Depot (0,1 ml/die) treatment. Spasms disappearance was observed in 6 patients (6/13 = 46%) treated with GVG (2 cryptogenic and 4 symptomatic) and in 10 patients (10/13 = 77%) treated with ACTH (6 cryptogenic and 7 symptomatic). GVG response occurred within 8 days. Treatment intolerance was observed in 2 cases, one treated with GVG and one treated with ACTH. After 3 months, side effects and relapses were more numerous in patients treated with ACTH. Thus, GVG can be suggested as first choice drug in infantile spasms treatment.

Translated title of the contributionVigabatrin versus ACTH as first line therapy in West syndrome
Original languageItalian
Pages (from-to)113-114
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number86-87
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Clinical Neurology

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