Vimentin and proliferating cell nuclear antigen (PCNA) expression in node-negative breast carcinomas and their correlations with pathologic variables and prognosis

M. C. Montesco, G. Zavagno, F. Meggiolaro, E. Frizzera, P. Mainente, M. Rupolo, M. Lise

Research output: Contribution to journalArticlepeer-review

Abstract

Vimentin and proliferating cell nuclear antigen (PCNA) immunohistochemical staining was performed in a series of 92 node-negative breast carcinomas and expression compared with tumour size, histological grade, nuclear grade, necrosis, lymphocytic infiltrate, oestrogen and progesterone receptors, and relapse rate. Vimentin was expressed in 13% of tumours and all positive cases were invasive ductal carcinomas. A strong relationship was noted between vimentin positivity, and both histological (P = 0.01) and nuclear grade (P = 0.02). The percentage of PCNA positive cells (PCNA index) varied from 0.2 to 70% (mean 27.45, median 28). PCNA index showed a significant correlation with histological (P = 0.001) and nuclear grade (P = 0.004). Furthermore vimentin positivity was significantly associated with high PCNA index (P = 0.002). With univariate analysis vimentin positivity and high PCNA index (> 28) were both significantly correlated with shorter disease free survival (P = 0.003 and P = 0.002 respectively) (median follow-up 84 months), while no other parameter reached significance. Using multivariate analysis PCNA index was statistically related to disease-free survival (P = 0.05), whereas vimentin lost its significance. Our results suggest that PCNA may be useful in identifying node-negative breast cancer patients at risk of recurrence.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalBreast
Volume4
Issue number3
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynaecology

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