VIN usual type - From the past to the future

Mario Preti, Sarah Igidbashian, Silvano Costa, Paolo Cristoforoni, Luciano Mariani, Massimo Origoni, Maria T. Sandri, Sara Boveri, Noemi Spolti, Laura Spinaci, Francesca Sanvito, Eleonora P. Preti, Adriana Falasca, Gianluigi Radici, Leonardo Micheletti

Research output: Contribution to journalArticle

Abstract

Usual vulvar intraepithelial neoplasia (uVIN) is the most common VIN type, generally related to a human papillomavirus (HPV) infection, predominantly type 16. The incidence of uVIN has been increasing over the last decades, and a bimodal peak is observed at the age of 40-44 and over 55 years. Almost 40% of patients with uVIN have a past, concomitant or future HPV-associated lesion of the lower genital tract. HPV-related malignancies are associated with a persistent HPV infection. The host immune response is of crucial importance in determining clearance or persistence of both HPV infections and HPV-related VIN. About 60% of the patients present with symptoms. Clinical features of uVIN vary in site, number, size, shape, colour, and thickness of lesions. Multicentric disease is often present. Most uVIN lesions are positive at immunohistochemistry to p16ink4a and p14arf, but negative to p53.

Original languageEnglish
Article number531
Journalecancermedicalscience
Volume9
DOIs
Publication statusPublished - Apr 29 2015

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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