Vincristine sulfate for the treatment of thrombotic thrombocytopenic purpura refractory to plasma-exchange

E. Bobbio-Pallavicini, C. Porta, R. Centurioni, L. Gugliotta, N. Vianelli, F. Tacconi, A. Billio, E. Ascari, O. Prinoth, M. Rubertelli, G. Ongaro, F. Rodeghiero, C. Perotti, G. Busnach, G. Cambie, A. Canevari, M. Carotenuto, G. Leda, G. Bertrand

Research output: Contribution to journalArticlepeer-review

Abstract

Among all the patients treated by the Italian Cooperative Group for TTP, we retrospectively reviewed the results obtained using vincristine (VCR) in 8 TTP patients (4 men and 4 women, average age: 39.25 years, range: 23-48) who did not respond to combined apheretic and pharmacologic treatment. All patients, after failing to respond to treatment, were started on VCR at the dose of 2 mg, i.v., once a week. Despite this treatment, 4 patients (50%) died 1, 7, 12 and 25 days after the first VCR dose, respectively. The other 4 patients who received VCR achieved complete remission 24, 30, 40 and 50 days from the beginning of the treatment. Total doses of VCR ranged from 2 to 6 mg in the deceased group, and from 6 to 14 mg in the cured patients. In our experience, VCR is a promising agent to treat TPP patients resistant to conventional plasma-exchange and pharmacologic therapy.

Original languageEnglish
Pages (from-to)222-226
Number of pages5
JournalEuropean Journal of Haematology
Volume52
Issue number4
Publication statusPublished - 1994

Keywords

  • plasma-exchange
  • refractory disease
  • TTP
  • vincristine

ASJC Scopus subject areas

  • Hematology

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