Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes

P. C. Marchisio; L. Bergui; G. C. Corbascio; O. Cremona; N. D&apos;Urso; M. Schena; L. Tesio; F. Caligaris-Cappio

Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes

P. C. Marchisio, L. Bergui, G. C. Corbascio, O. Cremona, N. D'Urso, M. Schena, L. Tesio, F. Caligaris-Cappio

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The microanatomy of the dot-shaped, close-contact sites called podosomes and the mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin, and β ₂ integrin (CD18) rings surround an F-actin core; (2) the β ₁ integrin is localized within the F-actin core; (3) the β ₃ integrin is not present. This distribution and organization of adhesion-related molecules appears to be unique to B-CLL lymphocytes, since it has not been observed in normal B cells. B-CLL adhesion and podosome formation are inhibited by the synthetic peptide GRGDSP that contains the Arg-Gly-Asp (RGD) sequence.

Original language	English
Pages (from-to)	830-833
Number of pages	4
Journal	Blood
Volume	72
Issue number	2
Publication status	Published - 1988

ASJC Scopus subject areas

Hematology

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title = "Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes",

abstract = "The microanatomy of the dot-shaped, close-contact sites called podosomes and the mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin, and β 2 integrin (CD18) rings surround an F-actin core; (2) the β 1 integrin is localized within the F-actin core; (3) the β 3 integrin is not present. This distribution and organization of adhesion-related molecules appears to be unique to B-CLL lymphocytes, since it has not been observed in normal B cells. B-CLL adhesion and podosome formation are inhibited by the synthetic peptide GRGDSP that contains the Arg-Gly-Asp (RGD) sequence.",

author = "Marchisio, {P. C.} and L. Bergui and Corbascio, {G. C.} and O. Cremona and N. D'Urso and M. Schena and L. Tesio and F. Caligaris-Cappio",

year = "1988",

language = "English",

volume = "72",

pages = "830--833",

journal = "Blood",

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T1 - Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes

AU - Marchisio, P. C.

AU - Bergui, L.

AU - Corbascio, G. C.

AU - Cremona, O.

AU - D'Urso, N.

AU - Schena, M.

AU - Tesio, L.

AU - Caligaris-Cappio, F.

PY - 1988

Y1 - 1988

N2 - The microanatomy of the dot-shaped, close-contact sites called podosomes and the mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin, and β 2 integrin (CD18) rings surround an F-actin core; (2) the β 1 integrin is localized within the F-actin core; (3) the β 3 integrin is not present. This distribution and organization of adhesion-related molecules appears to be unique to B-CLL lymphocytes, since it has not been observed in normal B cells. B-CLL adhesion and podosome formation are inhibited by the synthetic peptide GRGDSP that contains the Arg-Gly-Asp (RGD) sequence.

AB - The microanatomy of the dot-shaped, close-contact sites called podosomes and the mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin, and β 2 integrin (CD18) rings surround an F-actin core; (2) the β 1 integrin is localized within the F-actin core; (3) the β 3 integrin is not present. This distribution and organization of adhesion-related molecules appears to be unique to B-CLL lymphocytes, since it has not been observed in normal B cells. B-CLL adhesion and podosome formation are inhibited by the synthetic peptide GRGDSP that contains the Arg-Gly-Asp (RGD) sequence.

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