Abstract
The microanatomy of the dot-shaped, close-contact sites called podosomes and the mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin, and β 2 integrin (CD18) rings surround an F-actin core; (2) the β 1 integrin is localized within the F-actin core; (3) the β 3 integrin is not present. This distribution and organization of adhesion-related molecules appears to be unique to B-CLL lymphocytes, since it has not been observed in normal B cells. B-CLL adhesion and podosome formation are inhibited by the synthetic peptide GRGDSP that contains the Arg-Gly-Asp (RGD) sequence.
Original language | English |
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Pages (from-to) | 830-833 |
Number of pages | 4 |
Journal | Blood |
Volume | 72 |
Issue number | 2 |
Publication status | Published - 1988 |
ASJC Scopus subject areas
- Hematology