Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes

P. C. Marchisio, L. Bergui, G. C. Corbascio, O. Cremona, N. D'Urso, M. Schena, L. Tesio, F. Caligaris-Cappio

Research output: Contribution to journalArticlepeer-review

Abstract

The microanatomy of the dot-shaped, close-contact sites called podosomes and the mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin, and β 2 integrin (CD18) rings surround an F-actin core; (2) the β 1 integrin is localized within the F-actin core; (3) the β 3 integrin is not present. This distribution and organization of adhesion-related molecules appears to be unique to B-CLL lymphocytes, since it has not been observed in normal B cells. B-CLL adhesion and podosome formation are inhibited by the synthetic peptide GRGDSP that contains the Arg-Gly-Asp (RGD) sequence.

Original languageEnglish
Pages (from-to)830-833
Number of pages4
JournalBlood
Volume72
Issue number2
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Hematology

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