Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes

P. C. Marchisio, L. Bergui, G. C. Corbascio, O. Cremona, N. D'Urso, M. Schena, L. Tesio, F. Caligaris-Cappio

Research output: Contribution to journalArticle

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Abstract

The microanatomy of the dot-shaped, close-contact sites called podosomes and the mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin, and β 2 integrin (CD18) rings surround an F-actin core; (2) the β 1 integrin is localized within the F-actin core; (3) the β 3 integrin is not present. This distribution and organization of adhesion-related molecules appears to be unique to B-CLL lymphocytes, since it has not been observed in normal B cells. B-CLL adhesion and podosome formation are inhibited by the synthetic peptide GRGDSP that contains the Arg-Gly-Asp (RGD) sequence.

Original languageEnglish
Pages (from-to)830-833
Number of pages4
JournalBlood
Volume72
Issue number2
Publication statusPublished - 1988

Fingerprint

Talin
Vinculin
Lymphocytes
B-Cell Chronic Lymphocytic Leukemia
Integrins
B-Lymphocytes
Adhesion
glycyl-arginyl-glycyl-aspartyl-seryl-proline
Actins
Cells
Peptides
Molecules
Podosomes

ASJC Scopus subject areas

  • Hematology

Cite this

Marchisio, P. C., Bergui, L., Corbascio, G. C., Cremona, O., D'Urso, N., Schena, M., ... Caligaris-Cappio, F. (1988). Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes. Blood, 72(2), 830-833.

Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes. / Marchisio, P. C.; Bergui, L.; Corbascio, G. C.; Cremona, O.; D'Urso, N.; Schena, M.; Tesio, L.; Caligaris-Cappio, F.

In: Blood, Vol. 72, No. 2, 1988, p. 830-833.

Research output: Contribution to journalArticle

Marchisio, PC, Bergui, L, Corbascio, GC, Cremona, O, D'Urso, N, Schena, M, Tesio, L & Caligaris-Cappio, F 1988, 'Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes', Blood, vol. 72, no. 2, pp. 830-833.
Marchisio PC, Bergui L, Corbascio GC, Cremona O, D'Urso N, Schena M et al. Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes. Blood. 1988;72(2):830-833.
Marchisio, P. C. ; Bergui, L. ; Corbascio, G. C. ; Cremona, O. ; D'Urso, N. ; Schena, M. ; Tesio, L. ; Caligaris-Cappio, F. / Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes. In: Blood. 1988 ; Vol. 72, No. 2. pp. 830-833.
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AU - Bergui, L.

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AU - D'Urso, N.

AU - Schena, M.

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