Abstract
The microanatomy of the dot-shaped, close-contact sites called podosomes and the mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin, and β 2 integrin (CD18) rings surround an F-actin core; (2) the β 1 integrin is localized within the F-actin core; (3) the β 3 integrin is not present. This distribution and organization of adhesion-related molecules appears to be unique to B-CLL lymphocytes, since it has not been observed in normal B cells. B-CLL adhesion and podosome formation are inhibited by the synthetic peptide GRGDSP that contains the Arg-Gly-Asp (RGD) sequence.
| Original language | English |
|---|---|
| Pages (from-to) | 830-833 |
| Number of pages | 4 |
| Journal | Blood |
| Volume | 72 |
| Issue number | 2 |
| Publication status | Published - 1988 |
Fingerprint
ASJC Scopus subject areas
- Hematology
Cite this
Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes. / Marchisio, P. C.; Bergui, L.; Corbascio, G. C.; Cremona, O.; D'Urso, N.; Schena, M.; Tesio, L.; Caligaris-Cappio, F.
In: Blood, Vol. 72, No. 2, 1988, p. 830-833.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes
AU - Marchisio, P. C.
AU - Bergui, L.
AU - Corbascio, G. C.
AU - Cremona, O.
AU - D'Urso, N.
AU - Schena, M.
AU - Tesio, L.
AU - Caligaris-Cappio, F.
PY - 1988
Y1 - 1988
N2 - The microanatomy of the dot-shaped, close-contact sites called podosomes and the mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin, and β 2 integrin (CD18) rings surround an F-actin core; (2) the β 1 integrin is localized within the F-actin core; (3) the β 3 integrin is not present. This distribution and organization of adhesion-related molecules appears to be unique to B-CLL lymphocytes, since it has not been observed in normal B cells. B-CLL adhesion and podosome formation are inhibited by the synthetic peptide GRGDSP that contains the Arg-Gly-Asp (RGD) sequence.
AB - The microanatomy of the dot-shaped, close-contact sites called podosomes and the mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin, and β 2 integrin (CD18) rings surround an F-actin core; (2) the β 1 integrin is localized within the F-actin core; (3) the β 3 integrin is not present. This distribution and organization of adhesion-related molecules appears to be unique to B-CLL lymphocytes, since it has not been observed in normal B cells. B-CLL adhesion and podosome formation are inhibited by the synthetic peptide GRGDSP that contains the Arg-Gly-Asp (RGD) sequence.
UR - http://www.scopus.com/inward/record.url?scp=0023706105&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023706105&partnerID=8YFLogxK
M3 - Article
C2 - 3135866
AN - SCOPUS:0023706105
VL - 72
SP - 830
EP - 833
JO - Blood
JF - Blood
SN - 0006-4971
IS - 2
ER -