A phase II evaluation of Vinorelbine is of interest in mediterranean Kaposi's sarcoma (MKS) because of the well-known activity of the natural Vinca alkaloids in this disease. Fifteen patients, both chemonaive and pretreated, were treated with Vinorelbina at the close level of 17.5 mg/sqm every 2 weeks, 5 times, then 30 mg/sqm every 3 weeks until maximal response (complete regression, or partial regression), followed by 3 consolidation courses. A partial regression was obtained in 9/15 (60%) patients, with higher activity in previously untreated patients as compared to pretreated patients. The duration of remission was 6 months in the first group and 2 months in the second one. The median survival (all patients) was 13+ months. Vinorelbine is an active drug in MKS and needs more extensive, evaluation in large, cooperative clinical trials.
|Number of pages||3|
|Journal||European Journal of Dermatology|
|Publication status||Published - 1995|
- Mediterranean Kaposi's sarcoma
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