TY - JOUR
T1 - Vinorelbine is an effective and safe drug for AIDS-related Kaposi's sarcoma
T2 - Results of a phase II study
AU - Nasti, Guglielmo
AU - Errante, Domenico
AU - Talamini, Renato
AU - Rizzardini, Giuliano
AU - Fasan, Marco
AU - Landonio, Giuseppe
AU - Zeroli, Claudia
AU - Chichino, Guido
AU - Nigra, Ezio
AU - Vaccher, Emanuela
AU - Tirelli, Umberto
PY - 2000/4
Y1 - 2000/4
N2 - Purpose: To assess the safety and efficacy of vinorelbine in patients with AIDS-related Kaposi's sarcoma (KS). Patients and Methods: From December 1994 to May 1997, within the Italian Cooperative Group on AIDS and Tumors, we enrolled 36 patients with AIDS-related KS who experienced disease progression after one or more regimens of systemic chemotherapy. Patients were treated with vinorelbine 30 mg/m2 every 2 weeks by intravenous bolus. Results: Of 35 assessable patients, three (9%) had a clinical complete response and 12 (34%) had a partial remission, for an overall objective response rate of 43% (95% confidence interval, 26% to 61%). For the 15 patients with objective responses, the median duration of response from the beginning of therapy until the development of progression was 176 days, whereas the median progression-free survival and the median survival durations for 35 assessable patients wore 151 days and 216 days, respectively. Vinorelbine also induced responses in patients who had become resistant to regimens that included other vinca alkaloids. Overall, vinorelbine was well tolerated. Toxicity, including neurologic toxicity, was mild and reversible. Neutropenia was the most frequent dose-limiting toxicity. Conclusion: Vinorelbine is safe and effective in the treatment of patients with advanced KS who have been previously treated with one or more chemotherapy regimens. (C) 2000 by American Society of Clinical Oncology.
AB - Purpose: To assess the safety and efficacy of vinorelbine in patients with AIDS-related Kaposi's sarcoma (KS). Patients and Methods: From December 1994 to May 1997, within the Italian Cooperative Group on AIDS and Tumors, we enrolled 36 patients with AIDS-related KS who experienced disease progression after one or more regimens of systemic chemotherapy. Patients were treated with vinorelbine 30 mg/m2 every 2 weeks by intravenous bolus. Results: Of 35 assessable patients, three (9%) had a clinical complete response and 12 (34%) had a partial remission, for an overall objective response rate of 43% (95% confidence interval, 26% to 61%). For the 15 patients with objective responses, the median duration of response from the beginning of therapy until the development of progression was 176 days, whereas the median progression-free survival and the median survival durations for 35 assessable patients wore 151 days and 216 days, respectively. Vinorelbine also induced responses in patients who had become resistant to regimens that included other vinca alkaloids. Overall, vinorelbine was well tolerated. Toxicity, including neurologic toxicity, was mild and reversible. Neutropenia was the most frequent dose-limiting toxicity. Conclusion: Vinorelbine is safe and effective in the treatment of patients with advanced KS who have been previously treated with one or more chemotherapy regimens. (C) 2000 by American Society of Clinical Oncology.
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M3 - Article
C2 - 10735904
AN - SCOPUS:0034037096
VL - 18
SP - 1550
EP - 1557
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
SN - 0732-183X
IS - 7
ER -