Vinorelbine neurotoxicity: Clinical and neurophysiological findings in 23 patients

A. Pace, L. Bove, C. Nisticò, M. Ranuzzi, P. Innocenti, A. Pietrangeli, E. Terzoli, B. Jandolo

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Vinorelbine (5'-noranhydrovinblastine) is a new semisynthetic antineoplastic vinca alkaloid which interferes with axonal transport, inducing spiralisation of axonal microtubules and resulting in peripheral neurotoxicity. A prospective detailed neurological and electrophysiological evaluation was performed in 23 patients treated with 25 mg vinorelbine a week. All patients developed a sensory-motor distal symmetric axonal neuropathy. The neurotoxicity increased with cumulative vinorelbine doses and peripheral neuropathy was mild or moderate in most patients. After discontinuation of vinorelbine treatment, neuropathic signs and symptoms were partially reversible.

Original languageEnglish
Pages (from-to)409-411
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume61
Issue number4
Publication statusPublished - Oct 1996

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Vinca Alkaloids
Axonal Transport
Peripheral Nervous System Diseases
Microtubules
Antineoplastic Agents
Signs and Symptoms
vinorelbine
Therapeutics

Keywords

  • Neuroprotection
  • Neurotoxicity
  • Vinorelbine

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Pace, A., Bove, L., Nisticò, C., Ranuzzi, M., Innocenti, P., Pietrangeli, A., ... Jandolo, B. (1996). Vinorelbine neurotoxicity: Clinical and neurophysiological findings in 23 patients. Journal of Neurology, Neurosurgery and Psychiatry, 61(4), 409-411.

Vinorelbine neurotoxicity : Clinical and neurophysiological findings in 23 patients. / Pace, A.; Bove, L.; Nisticò, C.; Ranuzzi, M.; Innocenti, P.; Pietrangeli, A.; Terzoli, E.; Jandolo, B.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 61, No. 4, 10.1996, p. 409-411.

Research output: Contribution to journalArticle

Pace, A, Bove, L, Nisticò, C, Ranuzzi, M, Innocenti, P, Pietrangeli, A, Terzoli, E & Jandolo, B 1996, 'Vinorelbine neurotoxicity: Clinical and neurophysiological findings in 23 patients', Journal of Neurology, Neurosurgery and Psychiatry, vol. 61, no. 4, pp. 409-411.
Pace A, Bove L, Nisticò C, Ranuzzi M, Innocenti P, Pietrangeli A et al. Vinorelbine neurotoxicity: Clinical and neurophysiological findings in 23 patients. Journal of Neurology, Neurosurgery and Psychiatry. 1996 Oct;61(4):409-411.
Pace, A. ; Bove, L. ; Nisticò, C. ; Ranuzzi, M. ; Innocenti, P. ; Pietrangeli, A. ; Terzoli, E. ; Jandolo, B. / Vinorelbine neurotoxicity : Clinical and neurophysiological findings in 23 patients. In: Journal of Neurology, Neurosurgery and Psychiatry. 1996 ; Vol. 61, No. 4. pp. 409-411.
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