Vinorelbine treatment of advanced non-small cell lung cancer with special emphasis on elderly patients

A. Veronesi, D. Crivellari, M. D. Magri, G. Cartel, M. Mansutti, S. Foladore, S. Monfardini

Research output: Contribution to journalArticle

Abstract

The aim of this study was to investigate the activity and the toxicity of vinorelbine (VNB) in a population of patients with locally advanced inoperable or metastatic non-small cell lung cancer (NSCLC) including elderly patients unfit for cisplatin-based chemotherapy. VNB was administered at a dose of 25-30 mg/m2, intravenously, weekly until progression. Of the 83 patients who entered the study (median age 63 years, number of patients aged 3=70 years = 23, median performance status = SO, stage IV in 58 patients, previous chemotherapy in 15 patients), 76 were évaluable. One complete remission and 22 partial remissions were noted (30.2% réponse rate). Toxicity was mild. Median survival was 9 months. No effect of age upon outcome was detected. Thus, single agent VNB is a reasonable option for advanced NSCLC, particularly in elderly patients.

Original languageEnglish
Pages (from-to)1803-1808
Number of pages6
JournalEuropean Journal of Cancer
Volume32
Issue number10
Publication statusPublished - 1996

Keywords

  • Elderly patients
  • Non-small cell lung cancer
  • Vinorelbine

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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    Veronesi, A., Crivellari, D., Magri, M. D., Cartel, G., Mansutti, M., Foladore, S., & Monfardini, S. (1996). Vinorelbine treatment of advanced non-small cell lung cancer with special emphasis on elderly patients. European Journal of Cancer, 32(10), 1803-1808.