TY - JOUR
T1 - Vinorelbine treatment of recurrent salivary gland carcinomas
AU - Airoldi, Mario
AU - Bumma, Cesare
AU - Bertetto, Oscar
AU - Gabriele, Pietro
AU - Succo, Giovanni
AU - Pedani, Fulvia
PY - 1998
Y1 - 1998
N2 - Twenty patients (13 males, females, median age 61 years, range 27-64) with recurrent adenocarcinoma-like tumors of major (10 patients) and minor (10 patients) salivary gland origin (13 adenoid cystic carcinoma, 5 adenocarcinoma, 1 malignant mixed tumor, 1 undifferentiated carcinoma) were treated with vinorelbine at the dose of 30 mg/m2 IV weekly. Sixteen patients had been previously treated with surgery + radiation, 3 with surgery + radiotherapy + Novantrone® and 1 with radiotherapy alone. Nine patients had local recurrence, 2 local relapse + metastasis and 9 metastasis alone. Site of metastases are: lung (7), bone (1), lung + bone (2), lung + bone + lymph- node + skin (1). Overall 174 courses were given (median 9, range 6-19). Responses were: PR in 4 patients (200%) with a median duration of 6 months (3-9), 9 NC (45%) with a median duration of 3.5 months and 7 PD (35%). The median survival time was 10 months for PR/NC patients, 4 months for non- responders. Median overall survival was 7 months. Vinorelbine has a moderate activity in these very advanced cases.
AB - Twenty patients (13 males, females, median age 61 years, range 27-64) with recurrent adenocarcinoma-like tumors of major (10 patients) and minor (10 patients) salivary gland origin (13 adenoid cystic carcinoma, 5 adenocarcinoma, 1 malignant mixed tumor, 1 undifferentiated carcinoma) were treated with vinorelbine at the dose of 30 mg/m2 IV weekly. Sixteen patients had been previously treated with surgery + radiation, 3 with surgery + radiotherapy + Novantrone® and 1 with radiotherapy alone. Nine patients had local recurrence, 2 local relapse + metastasis and 9 metastasis alone. Site of metastases are: lung (7), bone (1), lung + bone (2), lung + bone + lymph- node + skin (1). Overall 174 courses were given (median 9, range 6-19). Responses were: PR in 4 patients (200%) with a median duration of 6 months (3-9), 9 NC (45%) with a median duration of 3.5 months and 7 PD (35%). The median survival time was 10 months for PR/NC patients, 4 months for non- responders. Median overall survival was 7 months. Vinorelbine has a moderate activity in these very advanced cases.
KW - Chemotherapy
KW - Salivary gland tumors
KW - Vinorelbine
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M3 - Article
C2 - 9835866
AN - SCOPUS:0031739684
VL - 85
SP - 892
EP - 894
JO - Bulletin du Cancer
JF - Bulletin du Cancer
SN - 0007-4551
IS - 10
ER -