VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas

Daniela Oliva, Simonetta Nicosia, Anna Spada, Giuliana Giannattasio

Research output: Contribution to journalArticle

Abstract

The effect of vasoactive intestinal polypeptide (VIP) on in vitro ACTH release and adenylate cyclase activity was investigated in human ACTH-secreting pituitary adenomas from 4 patients with Cushing's disease and 2 patients with Nelson's syndrome. In all the tumors tested, VIP elicited a dose-dependent stimulation of hormone release from adenoma fragments (90-247% at 10-7 M VIP) and of cAMP formation in membrane preparations (75-140% at 3×10-6 M VIP). Therefore a role of VIP in the control of ACTH secretion in human ACTH-secreting adenomas is suggested; a cAMP-dependent mechanism of action can also be hypothesized.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalEuropean Journal of Pharmacology
Volume83
Issue number1-2
DOIs
Publication statusPublished - Sep 10 1982

Fingerprint

ACTH-Secreting Pituitary Adenoma
Vasoactive Intestinal Peptide
Adenylyl Cyclases
Adrenocorticotropic Hormone
Adenoma
Nelson Syndrome
Pituitary ACTH Hypersecretion
Hormones
Membranes
Neoplasms

Keywords

  • ACTH
  • Adenylate cyclase
  • Pituitary adenomas
  • Vasoactive intestinal polypeptide

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas. / Oliva, Daniela; Nicosia, Simonetta; Spada, Anna; Giannattasio, Giuliana.

In: European Journal of Pharmacology, Vol. 83, No. 1-2, 10.09.1982, p. 101-105.

Research output: Contribution to journalArticle

Oliva, Daniela ; Nicosia, Simonetta ; Spada, Anna ; Giannattasio, Giuliana. / VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas. In: European Journal of Pharmacology. 1982 ; Vol. 83, No. 1-2. pp. 101-105.
@article{c5c25bca14db40b7bd7c50785fff0363,
title = "VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas",
abstract = "The effect of vasoactive intestinal polypeptide (VIP) on in vitro ACTH release and adenylate cyclase activity was investigated in human ACTH-secreting pituitary adenomas from 4 patients with Cushing's disease and 2 patients with Nelson's syndrome. In all the tumors tested, VIP elicited a dose-dependent stimulation of hormone release from adenoma fragments (90-247{\%} at 10-7 M VIP) and of cAMP formation in membrane preparations (75-140{\%} at 3×10-6 M VIP). Therefore a role of VIP in the control of ACTH secretion in human ACTH-secreting adenomas is suggested; a cAMP-dependent mechanism of action can also be hypothesized.",
keywords = "ACTH, Adenylate cyclase, Pituitary adenomas, Vasoactive intestinal polypeptide",
author = "Daniela Oliva and Simonetta Nicosia and Anna Spada and Giuliana Giannattasio",
year = "1982",
month = "9",
day = "10",
doi = "10.1016/0014-2999(82)90291-6",
language = "English",
volume = "83",
pages = "101--105",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas

AU - Oliva, Daniela

AU - Nicosia, Simonetta

AU - Spada, Anna

AU - Giannattasio, Giuliana

PY - 1982/9/10

Y1 - 1982/9/10

N2 - The effect of vasoactive intestinal polypeptide (VIP) on in vitro ACTH release and adenylate cyclase activity was investigated in human ACTH-secreting pituitary adenomas from 4 patients with Cushing's disease and 2 patients with Nelson's syndrome. In all the tumors tested, VIP elicited a dose-dependent stimulation of hormone release from adenoma fragments (90-247% at 10-7 M VIP) and of cAMP formation in membrane preparations (75-140% at 3×10-6 M VIP). Therefore a role of VIP in the control of ACTH secretion in human ACTH-secreting adenomas is suggested; a cAMP-dependent mechanism of action can also be hypothesized.

AB - The effect of vasoactive intestinal polypeptide (VIP) on in vitro ACTH release and adenylate cyclase activity was investigated in human ACTH-secreting pituitary adenomas from 4 patients with Cushing's disease and 2 patients with Nelson's syndrome. In all the tumors tested, VIP elicited a dose-dependent stimulation of hormone release from adenoma fragments (90-247% at 10-7 M VIP) and of cAMP formation in membrane preparations (75-140% at 3×10-6 M VIP). Therefore a role of VIP in the control of ACTH secretion in human ACTH-secreting adenomas is suggested; a cAMP-dependent mechanism of action can also be hypothesized.

KW - ACTH

KW - Adenylate cyclase

KW - Pituitary adenomas

KW - Vasoactive intestinal polypeptide

UR - http://www.scopus.com/inward/record.url?scp=0019945132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019945132&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(82)90291-6

DO - 10.1016/0014-2999(82)90291-6

M3 - Article

C2 - 6290240

AN - SCOPUS:0019945132

VL - 83

SP - 101

EP - 105

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1-2

ER -