VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas

Daniela Oliva, Simonetta Nicosia, Anna Spada, Giuliana Giannattasio

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of vasoactive intestinal polypeptide (VIP) on in vitro ACTH release and adenylate cyclase activity was investigated in human ACTH-secreting pituitary adenomas from 4 patients with Cushing's disease and 2 patients with Nelson's syndrome. In all the tumors tested, VIP elicited a dose-dependent stimulation of hormone release from adenoma fragments (90-247% at 10-7 M VIP) and of cAMP formation in membrane preparations (75-140% at 3×10-6 M VIP). Therefore a role of VIP in the control of ACTH secretion in human ACTH-secreting adenomas is suggested; a cAMP-dependent mechanism of action can also be hypothesized.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalEuropean Journal of Pharmacology
Volume83
Issue number1-2
DOIs
Publication statusPublished - Sep 10 1982

Keywords

  • ACTH
  • Adenylate cyclase
  • Pituitary adenomas
  • Vasoactive intestinal polypeptide

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Fingerprint Dive into the research topics of 'VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas'. Together they form a unique fingerprint.

Cite this