Viral and host immune regulatory mechanisms in hepatitis C virus infection

Mario U. Mondelli; Vincenzo Barnaba

doi:10.1097/00042737-200604000-00004

Viral and host immune regulatory mechanisms in hepatitis C virus infection

Mario U. Mondelli, Vincenzo Barnaba

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Recent studies suggest that liver inflammation in chronic hepatitis C virus (HCV) infection is controlled by several mechanisms, including host regulatory immune responses and viral polypeptides interacting with cells involved in innate and adaptive immunity. This article provides an overview about current thinking on host-pathogen symbiotic relationship in HCV infection and its significance with respect to pathogenesis. Special emphasis is given to regulatory T-cell subsets which have recently received attention and which are thought to play a major role in persistent viral infections such as HCV.

Original language	English
Pages (from-to)	327-331
Number of pages	5
Journal	European Journal of Gastroenterology and Hepatology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1097/00042737-200604000-00004
Publication status	Published - Apr 2006

Keywords

Core
HCV
IL-10
Liver
Regulatory T cells

ASJC Scopus subject areas

Gastroenterology

Access to Document

10.1097/00042737-200604000-00004

Fingerprint Dive into the research topics of 'Viral and host immune regulatory mechanisms in hepatitis C virus infection'. Together they form a unique fingerprint.

Cite this

@article{64efbea3fbd243e9951dd2d5d172184b,

title = "Viral and host immune regulatory mechanisms in hepatitis C virus infection",

abstract = "Recent studies suggest that liver inflammation in chronic hepatitis C virus (HCV) infection is controlled by several mechanisms, including host regulatory immune responses and viral polypeptides interacting with cells involved in innate and adaptive immunity. This article provides an overview about current thinking on host-pathogen symbiotic relationship in HCV infection and its significance with respect to pathogenesis. Special emphasis is given to regulatory T-cell subsets which have recently received attention and which are thought to play a major role in persistent viral infections such as HCV.",

keywords = "Core, HCV, IL-10, Liver, Regulatory T cells",

author = "Mondelli, {Mario U.} and Vincenzo Barnaba",

year = "2006",

month = apr,

doi = "10.1097/00042737-200604000-00004",

language = "English",

volume = "18",

pages = "327--331",

journal = "European Journal of Gastroenterology and Hepatology",

issn = "0954-691X",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

TY - JOUR

T1 - Viral and host immune regulatory mechanisms in hepatitis C virus infection

AU - Mondelli, Mario U.

AU - Barnaba, Vincenzo

PY - 2006/4

Y1 - 2006/4

N2 - Recent studies suggest that liver inflammation in chronic hepatitis C virus (HCV) infection is controlled by several mechanisms, including host regulatory immune responses and viral polypeptides interacting with cells involved in innate and adaptive immunity. This article provides an overview about current thinking on host-pathogen symbiotic relationship in HCV infection and its significance with respect to pathogenesis. Special emphasis is given to regulatory T-cell subsets which have recently received attention and which are thought to play a major role in persistent viral infections such as HCV.

AB - Recent studies suggest that liver inflammation in chronic hepatitis C virus (HCV) infection is controlled by several mechanisms, including host regulatory immune responses and viral polypeptides interacting with cells involved in innate and adaptive immunity. This article provides an overview about current thinking on host-pathogen symbiotic relationship in HCV infection and its significance with respect to pathogenesis. Special emphasis is given to regulatory T-cell subsets which have recently received attention and which are thought to play a major role in persistent viral infections such as HCV.

KW - Core

KW - HCV

KW - IL-10

KW - Liver

KW - Regulatory T cells

UR - http://www.scopus.com/inward/record.url?scp=33645098016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645098016&partnerID=8YFLogxK

U2 - 10.1097/00042737-200604000-00004

DO - 10.1097/00042737-200604000-00004

M3 - Article

C2 - 16538102

AN - SCOPUS:33645098016

VL - 18

SP - 327

EP - 331

JO - European Journal of Gastroenterology and Hepatology

JF - European Journal of Gastroenterology and Hepatology

SN - 0954-691X

IS - 4

ER -

Viral and host immune regulatory mechanisms in hepatitis C virus infection

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this