Viral and host immune regulatory mechanisms in hepatitis C virus infection

Mario U. Mondelli, Vincenzo Barnaba

Research output: Contribution to journalArticlepeer-review


Recent studies suggest that liver inflammation in chronic hepatitis C virus (HCV) infection is controlled by several mechanisms, including host regulatory immune responses and viral polypeptides interacting with cells involved in innate and adaptive immunity. This article provides an overview about current thinking on host-pathogen symbiotic relationship in HCV infection and its significance with respect to pathogenesis. Special emphasis is given to regulatory T-cell subsets which have recently received attention and which are thought to play a major role in persistent viral infections such as HCV.

Original languageEnglish
Pages (from-to)327-331
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number4
Publication statusPublished - Apr 2006


  • Core
  • HCV
  • IL-10
  • Liver
  • Regulatory T cells

ASJC Scopus subject areas

  • Gastroenterology


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