Viral and host immune regulatory mechanisms in hepatitis C virus infection

Mario U. Mondelli; Vincenzo Barnaba

doi:10.1097/00042737-200604000-00004

Viral and host immune regulatory mechanisms in hepatitis C virus infection

Mario U. Mondelli, Vincenzo Barnaba

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Recent studies suggest that liver inflammation in chronic hepatitis C virus (HCV) infection is controlled by several mechanisms, including host regulatory immune responses and viral polypeptides interacting with cells involved in innate and adaptive immunity. This article provides an overview about current thinking on host-pathogen symbiotic relationship in HCV infection and its significance with respect to pathogenesis. Special emphasis is given to regulatory T-cell subsets which have recently received attention and which are thought to play a major role in persistent viral infections such as HCV.

Original language	English
Pages (from-to)	327-331
Number of pages	5
Journal	European Journal of Gastroenterology and Hepatology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1097/00042737-200604000-00004
Publication status	Published - Apr 2006

Keywords

Core
HCV
IL-10
Liver
Regulatory T cells

ASJC Scopus subject areas

Gastroenterology

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10.1097/00042737-200604000-00004

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AB - Recent studies suggest that liver inflammation in chronic hepatitis C virus (HCV) infection is controlled by several mechanisms, including host regulatory immune responses and viral polypeptides interacting with cells involved in innate and adaptive immunity. This article provides an overview about current thinking on host-pathogen symbiotic relationship in HCV infection and its significance with respect to pathogenesis. Special emphasis is given to regulatory T-cell subsets which have recently received attention and which are thought to play a major role in persistent viral infections such as HCV.

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KW - IL-10

KW - Liver

KW - Regulatory T cells

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Viral and host immune regulatory mechanisms in hepatitis C virus infection

Abstract

Keywords

ASJC Scopus subject areas

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