Viral clearance without destruction of infected cells during acute HBV infection

Luca G. Guidotti, Rosemary Rochford, Josan Chung, Max Shapiro, Robert Purcell, Francis V. Chisari

Research output: Contribution to journalArticle

Abstract

Viral clearance during hepatitis B virus (HBV) infection has been thought to reflect the destruction of infected hepatocytes by CD8 + T lymphocytes. However, in this study, HBV DNA was shown to largely disappear from the liver and the blood of acutely infected chimpanzees long before the peak of T cell infiltration and most of the liver disease. These results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and covalently closed circular viral DNA from the nucleus of infected cells.

Original languageEnglish
Pages (from-to)825-829
Number of pages5
JournalScience
Volume284
Issue number5415
DOIs
Publication statusPublished - Apr 30 1999

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ASJC Scopus subject areas

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Cite this

Guidotti, L. G., Rochford, R., Chung, J., Shapiro, M., Purcell, R., & Chisari, F. V. (1999). Viral clearance without destruction of infected cells during acute HBV infection. Science, 284(5415), 825-829. https://doi.org/10.1126/science.284.5415.825