Viral control of the SUMO pathway: Gam1, a model system

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Abstract

SUMO (small ubiquitin-related modifier) is a ubiquitin-like family member that is conjugated to its substrates through discrete enzymatic steps: activation, involving the E1 enzyme [SAE (SUMO-activating enzyme) 1-SAE2], conjugation, involving the E2 enzyme [Ubc9 (ubiquitin-conjugating enzyme 9)], and substrate modification, through the co-operation of Ubc9 and E3 protein ligases. Work from our laboratory has shown the first example of a viral protein, Gam1, that binds to the E1 heterodimer, inhibiting its function and causing a complete block of the SUMOylation pathway both in vivo and in vitro, followed by SAE1-SAE2 degradation. The mechanism by which a viral protein inactivates and subsequently degrades an essential cellular enzyme, arresting a key regulatory pathway, will be discussed. Although four distinct SUMO isoforms have been described, I will use SUMO to describe the entire system.

Original languageEnglish
Pages (from-to)1419-1421
Number of pages3
JournalBiochemical Society Transactions
Volume35
Issue number6
DOIs
Publication statusPublished - Dec 2007

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Keywords

  • E1 activating enzyme
  • Elongin (Elo)
  • Gam1
  • Small ubiquitin-related modifier (SUMO)
  • SUMOylation
  • Viral protein

ASJC Scopus subject areas

  • Biochemistry

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