Viral hepatitis and anti-phospholipid antibodies positivity: A systematic review and meta-analysis

Pasquale Ambrosino, Roberta Lupoli, Paolo Tarantino, Alessandro Di Minno, Luciano Tarantino, Matteo Nicola Dario Di Minno

Research output: Contribution to journalArticle

Abstract

Background: Anti-phospholipid antibodies positivity is associated with several clinical conditions, including infectious diseases. Aims: We performed a meta-analysis evaluating the association of hepatitis B and C with anti-phospholipid antibody positivity and with anti-phospholipid antibody-related thrombotic complications. Methods: Studies evaluating the association of viral hepatitis with anti-cardiolipin, anti-β2 glycoprotein-I and lupus anticoagulant antibodies and anti-phospholipid antibody-related thrombotic events were systematically searched. Results: 20 studies (2319 cases, 1901 controls) were included. The analyses showed that viral hepatitis is associated with the presence of anti-cardiolipin and anti-β2 glycoprotein-I antibodies. The association with anticardiolipin antibodies was confirmed in both hepatitis B (OR 11.22, 95% CI: 6.68-18.84) and hepatitis C (OR 11.26, 95% CI: 6.82-18.59). Similarly, compared to controls, anti-β2 glycoprotein-I antibodies were found more frequently in hepatitis B (OR 14.07, 95% CI: 3.06-64.66) and hepatitis C (OR 5.64, 95% CI: 1.69-18.77). Moreover, 11 studies (257 cases, 1079 controls) showed a higher prevalence of venous and/or arterial thrombosis in patients with hepatitis and anti-cardiolipin antibody positivity compared hepatitis alone (OR 3.29, 95% CI: 1.79-6.07). This result was consistently confirmed in hepatitis C (OR 3.64, 95% CI: 1.78-7.46) but not in hepatitis B. Conclusions: Viral hepatitis is significantly associated with anti-phospholipid antibody positivity and with anti-phospholipid antibody-related thrombotic complications.

Original languageEnglish
Pages (from-to)478-487
Number of pages10
JournalDigestive and Liver Disease
Volume47
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Anti-β2 glycoprotein-I antibodies
  • Anticardiolipin antibodies
  • Antiphospholipid antibodies
  • Viral hepatitis

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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    Ambrosino, P., Lupoli, R., Tarantino, P., Di Minno, A., Tarantino, L., & Di Minno, M. N. D. (2015). Viral hepatitis and anti-phospholipid antibodies positivity: A systematic review and meta-analysis. Digestive and Liver Disease, 47(6), 478-487. https://doi.org/10.1016/j.dld.2015.03.006