Viral Hepatitis: Etiology, Epidemiology, Transmission, Diagnostics, Treatment, and Prevention

Simone Lanini, Andrew Ustianowski, Raffaella Pisapia, Alimuddin Zumla, Giuseppe Ippolito

Research output: Contribution to journalReview articlepeer-review

Abstract

Viral hepatitis is a major global public health problem affecting hundreds of millions of people and is associated with significant morbidity and mortality. Five major biologically unrelated hepatotropic viruses cause most of the global burden of viral hepatitis. Hepatitis B and hepatitis C are associated with a significant number of chronic infections. Most deaths from viral hepatitis are due to hepatitis B and hepatitis C. An estimated 257 million people were living with HBV and 71 million people were living with HCV. Most people are asymptomatic. New diagnostics and highly effective, pangenotypic direct-acting antivirals provide opportunities to cure and eradicate chronic hepatitis C virus infection.

Original languageEnglish
Pages (from-to)1045-1062
Number of pages18
JournalInfectious Disease Clinics of North America
Volume33
Issue number4
DOIs
Publication statusPublished - Dec 1 2019

Keywords

  • Acute viral hepatitis
  • Chronic viral hepatitis
  • HAV
  • HBV
  • HCV
  • HDV
  • HEV

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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