Viral, host and therapeutic factors affecting T-cell recovery in virologically controlled HIV patients

Carmela Pinnetti, Alessandra Bandera, Davide Mangioni, Andrea Gori

Research output: Contribution to journalArticlepeer-review

Abstract

Despite suppressive combination antiretroviral therapy, a considerable proportion of HIV-infected patients do not achieve adequate immune recovery in terms of the CD4+ T-cell count, although they have controlled viremia values. Many questions remain for clinicians in the management of these patients, defined as immunological nonresponders, including questions about the mechanisms underlying the lack of immune restoration and possible therapeutic approaches to this particular group of patients.

Original languageEnglish
Pages (from-to)911-921
Number of pages11
JournalFuture Virology
Volume7
Issue number9
DOIs
Publication statusPublished - Sep 2012

Keywords

  • antiretroviral therapy
  • HIV infection
  • immune reconstitution

ASJC Scopus subject areas

  • Virology

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