Plasma and cerebrospinal fluid viral load levels were measured in 30 HIV-infected patients with neurological disorders. Albumin ratio (indicanting blood-brain barrier damage), Link's index (indicanting IgG intrathecal production) and cerebrospinal fluid electrophoresis (to consider oligoclonal IgG bands) were also considered. HIV can be found in cerebrospinal fluid of most patients (87%); cerebrospinal fluid levels were found to be significatively higher than the plasma ones in 5 patients. These results are in accordance with the theory that the Central Nervous System (CNS) can be considered as a viral resorvoire. Patients with nerological disorders and oligoclonal pattern have high viral load levels in cerebrospinal fluid (the double, compared with plasma levels). High CNS viral load levels can induce an intrathecal chronic immune stimulation.
|Translated title of the contribution||Viral load in cerebrospinal fluid: A new tool for the monitoring of HIV infection?|
|Number of pages||5|
|Journal||Trasfusione del Sangue|
|Publication status||Published - 1999|
ASJC Scopus subject areas
- Immunology and Allergy