Carica virale liquorale: Un nuovo strumento nel monitoraggio dell'infezione da HIV?

Translated title of the contribution: Viral load in cerebrospinal fluid: A new tool for the monitoring of HIV infection?

A. Terrile, P. Strada, A. M. Solda, A. Correggi, G. Tripodi, V. Picciche, A. Campanella, G. Cassola, G. Penco, N. Piersantelli, M. Anselmo, G. Astegiano, A. Leonardi, G. Ferrea, L. Corbella, G. Imberciadori

Research output: Contribution to journalArticle

Abstract

Plasma and cerebrospinal fluid viral load levels were measured in 30 HIV-infected patients with neurological disorders. Albumin ratio (indicanting blood-brain barrier damage), Link's index (indicanting IgG intrathecal production) and cerebrospinal fluid electrophoresis (to consider oligoclonal IgG bands) were also considered. HIV can be found in cerebrospinal fluid of most patients (87%); cerebrospinal fluid levels were found to be significatively higher than the plasma ones in 5 patients. These results are in accordance with the theory that the Central Nervous System (CNS) can be considered as a viral resorvoire. Patients with nerological disorders and oligoclonal pattern have high viral load levels in cerebrospinal fluid (the double, compared with plasma levels). High CNS viral load levels can induce an intrathecal chronic immune stimulation.

Translated title of the contributionViral load in cerebrospinal fluid: A new tool for the monitoring of HIV infection?
Original languageItalian
Pages (from-to)277-281
Number of pages5
JournalTrasfusione del Sangue
Volume44
Issue number5
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy

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    Terrile, A., Strada, P., Solda, A. M., Correggi, A., Tripodi, G., Picciche, V., Campanella, A., Cassola, G., Penco, G., Piersantelli, N., Anselmo, M., Astegiano, G., Leonardi, A., Ferrea, G., Corbella, L., & Imberciadori, G. (1999). Carica virale liquorale: Un nuovo strumento nel monitoraggio dell'infezione da HIV? Trasfusione del Sangue, 44(5), 277-281.