Viral-mediated expression of a constitutively active form of CREB in hippocampal neurons increases memory

Leonardo Restivo, Elisiarta Tafi, Martine Ammassari-Teule, Hélène Marie

Research output: Contribution to journalArticlepeer-review

Abstract

Synaptic activity-dependent phosphorylation of the transcription factor cAMP response element binding protein (CREB) leads to CREB-dependent gene transcription, a process thought to underlie long-term hippocampal synaptic plasticity and memory formation. We previously reported that increasing CREB activity in glutamatergic neurons enhances synaptic plasticity and neuronal excitability. Whether these modifications are sufficient to promote hippocampai-dependent memory formation was not determined. Here, we provide direct evidence that a brief increase in CREB-dependent transcription in either CA1 or DG neurons, using in vivo viral vectors, is sufficient to boost memory for contextual representations, as tested in the contextual fear conditioning task, without affecting motor, pain, or anxiety behaviors.

Original languageEnglish
Pages (from-to)228-234
Number of pages7
JournalHippocampus
Volume19
Issue number3
DOIs
Publication statusPublished - Mar 2009

Keywords

  • Contextual fear conditioning
  • CREB
  • Hippocampus
  • Memory
  • Viral vector

ASJC Scopus subject areas

  • Cognitive Neuroscience

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