Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers

Marconi Rego Barros, Talita Helena Araújo de Oliveira, Cristiane Moutinho Lagos de Melo, Aldo Venuti, Antonio Carlos de Freitas

Research output: Contribution to journalReview article

Abstract

The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human papillomavirus- (HPV-) related cancers. This virus is able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. Both TLRs and cytokines play a central role in HPV recognition, cell maturation and differentiation as well as immune signalling. Therefore, the imbalance of this sensitive control of the immune response is a key factor for developing immunotherapies, which strengthen the host immune system to accomplish an efficient defence against HPV and HPV-infected cells. Based on this, the review is aimed at exposing the HPV immune evasion mechanisms involving TLRs and cytokines and at discussing existing and potential immunotherapeutic TLR- and cytokine-related tools.

Original languageEnglish
Number of pages1
JournalJournal of Immunology Research
Volume2018
DOIs
Publication statusPublished - Jan 1 2018

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers'. Together they form a unique fingerprint.

  • Cite this