VIRO-immunological outcomes after 13-valent pneumococcal vaccination in HIV-1-infected individuals on stable virological suppression

Raffaele Dell'Acqua, Laura Galli, Andrea Poli, Andrea Mastrangelo, Monica Guffanti, Patrizia Tadini, Daniela Zandona, Anna Danise, Nicola Gianotti, Adriano Lazzarin, Antonella Castagna, Silvia Nozza

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Abstract

Background:Very limited data are available on the immunovirological outcomes after 13-valent pneumococcal conjugate vaccine (PCV13) in antiretroviral therapy (ART)-treated patients. The aim of this study was to assess the immune-virological outcomes in HIV-1-infected ART-treated patients on stable virological suppression who underwent pneumococcal conjugate vaccination.Methods:Retrospective, cohort study on ART-treated HIV-1-infected individuals, age at least 18 years, with three consecutive determinations of HIV-RNA less than 50 copies/ml before the administration of PCV13 (baseline) at San Raffaele Hospital and with at least two HIV-RNA values after vaccination.Results:Overall 1197 patients underwent PCV13 vaccination. During 6-month of follow-up (594 person-years of follow-up, PYFU), 12 confirmed virological failure and 35 viral blips were observed; the overall incidence rate of confirmed virological failure was 2.02 (95% confidence interval: 0.88-3.16) per 100-PYFU and the incidence rate of viral blips was 5.89 (95% confidence interval: 3.94-7.84) per 100-PYFU. Median CD4+ cell count change from baseline at 6 months was +10 cells/μl (interquartile range -67, +111; P = 0.0002). Median change in CD4+/CD8+ ratio was +0.02 (interquartile range -0.06, +0.11; P < 0.001).Conclusion:Viral blips and confirmed virological failures were rarely observed in patients on stable virological suppression in the first 6 months following vaccination with PCV13. In addition, no decrease of CD4+ cell count and CD4+/CD8+ ratio was recorded.

Original languageEnglish
Pages (from-to)1987-1994
Number of pages8
JournalAIDS
Volume33
Issue number13
DOIs
Publication statusPublished - Nov 1 2019

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Keywords

  • 13-valent pneumococcal conjugate vaccine
  • confirmed virological failure
  • HIV infection
  • vaccine
  • viral blip
  • virological suppression

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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