Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcoma

Elizabeth E. Brown, Denise Whitby, Francesco Vitale, Vickie Marshall, Georgina Mbisa, Christine Gamache, Carmela Lauria, Anthony J. Alberg, Diego Serraino, Paola Cordiali-Fei, Angelo Messina, James J. Goedert

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Classic Kaposi sarcoma (CKS) is an inflammatory-mediated neoplasm that develops in the presence of KS-associated herpesvirus (KSHV) and immune perturbation. In the current study, the authors compared CKS cases with age-matched and sex-matched KSHV-seropositive controls without human immunodeficiency virus-1 infection and markers of viral control, blood counts, CD4-positive and CD8-positive lymphocytes, and serum β-2-microglobulin and neopterin levels. METHODS. Viral loads were detected using real-time amplification of the KSHV-K6 and EBV-pol genes, anti-K8.1 (lytic) titers were detected by enzyme-linked immunoadsorbent assay, and antilatent nuclear antigen (LANA) titers were detected using immunofluorescence. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using logistic regression adjusted for sex, age, and study site. RESULTS. Peripheral blood mononuclear cells (PBMC) KSHV DNA detection (P ≤ .0001) and high KSHV lytic (>1:1745; P ≤ .0001) and latent (>1:102,400; P = .03) antibody titers were found to be positively associated with CKS risk. Antibody titers were higher in cases with lesions compared with cases without lesions (P ≤ .05). The detection of Epstein-Barr virus (EBV) DNA in PBMCs was not found to be associated with CKS (P = .95). Independent of PBMC KSHV DNA, CKS risk was found to be positively associated with reduced hematocrit (

Original languageEnglish
Pages (from-to)2282-2290
Number of pages9
JournalCancer
Volume107
Issue number9
DOIs
Publication statusPublished - Nov 1 2006

Keywords

  • Biomarker
  • Human herpesvirus-8
  • Immunity
  • Kaposi sarcoma
  • Kaposi sarcoma-associated herpesvirus

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Brown, E. E., Whitby, D., Vitale, F., Marshall, V., Mbisa, G., Gamache, C., Lauria, C., Alberg, A. J., Serraino, D., Cordiali-Fei, P., Messina, A., & Goedert, J. J. (2006). Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcoma. Cancer, 107(9), 2282-2290. https://doi.org/10.1002/cncr.22236