Virological and immunological response to antiretroviral regimens containing maraviroc in HIV type 1-infected patients in clinical practice: Role of different tropism testing results and of concomitant treatments

Barbara Rossetti, Claudia Bianco, Lara Ines Bellazzi, Bianca Bruzzone, Grazia Colao, Paola Corsi, Laura Monno, Gabriella Pagano, Stefania Paolucci, Grazia Punzi, Maurizio Setti, Maurizio Zazzi, Andrea De Luca

Research output: Contribution to journalArticle

Abstract

We assessed the immunovirological response to antiretroviral regimens containing maraviroc in HIV-infected viremic patients with viral tropism predicted by different assays. We selected antiretroviral treatment-experienced HIV-1-infected patients initiating regimens containing maraviroc after different phenotypic or genotypic viral tropism assays, with at least one HIV-1 RNA determination during follow-up. Survival analysis was employed to assess the virological response as time to HIV-1 RNA 10 higher: HR 1.29, 95% CI 1.05-1.60) and concomitant therapy with enfuvirtide (HR 2.05, 0.96-4.39) but not tropism assay results. Of 17 patients with baseline R5-tropic virus and available tropism results while viremic during follow-up on maraviroc, seven (41%) showed a tropism switch to non-R5 virus. A significant proportion of experienced patients treated with regimens containing maraviroc achieved virological response. The tropism test type used was not associated with immunovirological response and concomitant treatment with enfuvirtide increased the chance of immunological response. More than half of virological failures with maraviroc were not accompanied by tropism switch.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalAIDS Research and Human Retroviruses
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 1 2014

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases
  • Medicine(all)

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