TY - JOUR
T1 - Virological and immunological responses to HAART in asymptomatic therapy-naive HIV-1-infected subjects according to CD4 cell count
AU - Rizzardi, G. P.
AU - Tambussi, G.
AU - Bart, P. A.
AU - Chapuis, A. G.
AU - Lazzarin, A.
AU - Pantaleo, G.
PY - 2000
Y1 - 2000
N2 - Objective: When to start highly active antiretroviral therapy (HAART) in asymptomatic chronically HIV-1-infected subjects with CD4 cell counts of 300 x 106-500 x 106/l is debated extensively. Retrospective analyses of virological and immunological responses following HAART have been evaluated in both blood and lymph nodes according to pre-treatment levels of CD4 cells either above or below 500 x 106/l. Design: Open-label, observational, non-randomized, prospective study. Setting: Outpatients attending the Centre of Clinical Investigation in Infectious Diseases, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland. Participants: Fifty-four HIV-1-infected antiretroviral-naive subjects with CD4 cell count ≥ 250 x 106/l and plasma viraemia ≥ 5000 copies/ml who had been treated with HAART for at least 48 weeks. Controls were 49 HIV-negative subjects. Interventions: All patients received abacavir, nelfinavir, saquinavir soft gel capsules, and amprenavir in varying combinations for 72 weeks. Main outcome measures: The extent of immune reconstitution following HAART in 43 and 11 subjects with either more or fewer than 500 x 106 CD4 cells/l at baseline was evaluated in blood and lymph node, and compared with immunological measures observed in 49 HIV-negative controls. Results: After 48 weeks of therapy, plasma viraemia was suppressed effectively in both groups of patients. Normalization of both CD4 cell count in blood, divided equally between memory and naive cells, and percentage of CD4 cells in lymph nodes occurred in the two groups. Consistently, the net increase over baseline in CD4 cell count and in memory and naive CD4 subsets was greater in patients with fewer than 500 x 106 CD4 cells/l at baseline. Recovery of HIV-specific responses was similar in the two groups. Conclusions: This study suggests that virological and immunological responses are comparable in asymptomatic therapy-naive HIV-1-infected subjects with CD4 cell counts above or below 500 x 106/l. (C) 2000 Lippincott Williams and Wilkins.
AB - Objective: When to start highly active antiretroviral therapy (HAART) in asymptomatic chronically HIV-1-infected subjects with CD4 cell counts of 300 x 106-500 x 106/l is debated extensively. Retrospective analyses of virological and immunological responses following HAART have been evaluated in both blood and lymph nodes according to pre-treatment levels of CD4 cells either above or below 500 x 106/l. Design: Open-label, observational, non-randomized, prospective study. Setting: Outpatients attending the Centre of Clinical Investigation in Infectious Diseases, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland. Participants: Fifty-four HIV-1-infected antiretroviral-naive subjects with CD4 cell count ≥ 250 x 106/l and plasma viraemia ≥ 5000 copies/ml who had been treated with HAART for at least 48 weeks. Controls were 49 HIV-negative subjects. Interventions: All patients received abacavir, nelfinavir, saquinavir soft gel capsules, and amprenavir in varying combinations for 72 weeks. Main outcome measures: The extent of immune reconstitution following HAART in 43 and 11 subjects with either more or fewer than 500 x 106 CD4 cells/l at baseline was evaluated in blood and lymph node, and compared with immunological measures observed in 49 HIV-negative controls. Results: After 48 weeks of therapy, plasma viraemia was suppressed effectively in both groups of patients. Normalization of both CD4 cell count in blood, divided equally between memory and naive cells, and percentage of CD4 cells in lymph nodes occurred in the two groups. Consistently, the net increase over baseline in CD4 cell count and in memory and naive CD4 subsets was greater in patients with fewer than 500 x 106 CD4 cells/l at baseline. Recovery of HIV-specific responses was similar in the two groups. Conclusions: This study suggests that virological and immunological responses are comparable in asymptomatic therapy-naive HIV-1-infected subjects with CD4 cell counts above or below 500 x 106/l. (C) 2000 Lippincott Williams and Wilkins.
KW - Antiretroviral therapy
KW - CD4
KW - Cellular immunity
KW - Combination therapy
KW - Pathogenesis
KW - Protease inhibitors
KW - Viral load
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U2 - 10.1097/00002030-200010200-00006
DO - 10.1097/00002030-200010200-00006
M3 - Article
C2 - 11089613
AN - SCOPUS:0033758426
VL - 14
SP - 2257
EP - 2263
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 15
ER -