Virological rebound in human immunodeficiency virus-infected patients with or without residual viraemia

Results from an extended follow-up

N. Gianotti, L. Galli, S. Salpietro, M. Cernuschi, S. Bossolasco, M. Maillard, V. Spagnuolo, F. Canducci, M. Clementi, A. Lazzarin, A. Castagna

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV) -infected patients with HIV RNA loads of <50 copies/mL were followed-up for a median (interquartile range) of 30.8 (11.7-32.9) months to study the effect of residual viraemia (RV) on virological rebound (VR). At baseline, 446 (60.3%) patients had undetectable HIV RNA (group A) and 293 (39.7%) had RV (1-49 HIV RNA copies/mL, group B) by kinetic PCR. VR occurred in 4 (0.9%) patients in group A and in 12 (4.1%) patients in group B (p 0.007). Time to VR was shorter among patients of group B (Log-rank test: p 0.003). However, the proportion of VR was extremely low also among patients with RV.

Original languageEnglish
JournalClinical Microbiology and Infection
Volume19
Issue number12
DOIs
Publication statusPublished - Dec 2013

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Viremia
HIV
RNA
HIV-1
Polymerase Chain Reaction

Keywords

  • Antiretroviral therapy
  • Human immunodeficiency virus type 1viral load
  • Kinetic PCR
  • Virological failure
  • Virological rebound

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Virological rebound in human immunodeficiency virus-infected patients with or without residual viraemia : Results from an extended follow-up. / Gianotti, N.; Galli, L.; Salpietro, S.; Cernuschi, M.; Bossolasco, S.; Maillard, M.; Spagnuolo, V.; Canducci, F.; Clementi, M.; Lazzarin, A.; Castagna, A.

In: Clinical Microbiology and Infection, Vol. 19, No. 12, 12.2013.

Research output: Contribution to journalArticle

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AU - Cernuschi, M.

AU - Bossolasco, S.

AU - Maillard, M.

AU - Spagnuolo, V.

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