Virological response and retention in care according to time of starting ART in Italy: Data from the Icona Foundation Study cohort: Journal of Antimicrobial Chemotherapy

A. D'Arminio Monforte, A. Tavelli, A. Cozzi-Lepri, A. Castagna, S. Passerini, D. Francisci, A. Saracino, F. Maggiolo, G. Lapadula, E. Girardi, C.F. Perno, A. Antinori, M. Andreoni, F. Castelli, R. Cauda, G. Di Perri, M. Galli, R. Iardino, G. Ippolito, A. LazzarinG.C. Marchetti, G. Rezza, F. Von Schloesser, P. Viale, F. Ceccherini-Silberstein, S. Lo Caputo, C. Mussini, M. Puoti, F. Bai, C. Balotta, A. Bandera, S. Bonora, M. Borderi, A. Calcagno, A. Capetti, M.R. Capobianchi, S. Cicalini, A. Cingolani, P. Cinque, A. De Luca, A. Di Biagio, N. Gianotti, A. Gori, G. Guaraldi, M. Lichtner, G. Madeddu, L. Monno, S. Nozza, C. Pinnetti, E. Quiros Roldan, R. Rossotti, S. Rusconi, M.M. Santoro, L. Sarmati, I. Fanti, L. Galli, P. Lorenzini, A. Rodano, M. MacChia, F. Carletti, S. Carrara, A. Di Caro, S. Graziano, F. Petroni, G. Prota, S. Truffa, A. Giacometti, A. Costantini, V. Barocci, G. Angarano, E. Milano, C. Suardi, V. Donati, G. Verucchi, F. Castelnuovo, C. Minardi, B. Menzaghi, C. Abeli, B. Cacopardo, B. Celesia, J. Vecchiet, K. Falasca, A. Pan, S. Lorenzotti, L. Sighinolfi, D. Segala, P. Blanc, F. Vichi, G. Cassola, C. Viscoli, A. Alessandrini, N. Bobbio, G. Mazzarello, L. Fondaco, P. Bonfanti, C. Molteni, A. Chiodera, P. Milini, G. Nunnari, G. Pellicanò, G. Rizzardini, E.S. Cannizzo, M.C. Moioli, R. Piolini, D. Bernacchia, S. Salpietro, C. Tincati, C. Puzzolante, C. Migliorino, V. Sangiovanni, G. Borgia, V. Esposito, G. Di Flumeri, I. Gentile, V. Rizzo, A.M. Cattelan, S. Marinello, A. Cascio, M. Trizzino, E. Schiaroli, G. Parruti, F. Sozio, G. Magnani, M.A. Ursitti, A. Cristaudo, V. Vullo, R. Acinapura, D. Moschese, M. Capozzi, A. Mondi, M. Rivano Capparuccia, G. Iaiani, A. Latini, R. Gagliardini, M.M. Plazzi, G. De Girolamo, A. Vergori, M. Cecchetto, F. Viviani, A. De Vito, B. Rossetti, F. Montagnani, A. Franco, R. Fontana Del Vecchio, C. Di Giuli, P. Caramello, G.C. Orofino, M. Sciandra, M. Bassetti, A. Londero, V. Manfrin, G. Battagin, G. Starnini, A. Ialungo, Icona Foundation Study Group

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To describe: (i) factors associated with rapid and delayed ART initiation; (ii) rates of 12 week virological response; and (iii) virologically controlled retention in care by 1 year from ART initiation according to timing of start in a real-life setting. Methods: All individuals in the Icona cohort diagnosed with HIV in 2016-17 who initiated ART were grouped according to the time between HIV diagnosis and ART initiation: Group 1, ≤7 days; Group 2, 8-14 days; Group 3, 15-30 days; Group 4, 31-120 days; and Group 5, >120 days. Multivariable logistic regression models were used to identify factors associated with: (i) the probability of rapid (Group 1) and very delayed (Group 5) ART initiation; (ii) the 12 week virological response (by a modified snapshot algorithm); and (iii) the probability of retention in care at 1 year (on ART with HIV-RNA
Original languageEnglish
Pages (from-to)681-689
Number of pages9
JournalJ. Antimicrob. Chemother.
Volume75
Issue number3
DOIs
Publication statusPublished - 2020

Keywords

  • anti human immunodeficiency virus agent
  • adult
  • antiretroviral therapy
  • Article
  • CD4 lymphocyte count
  • cohort analysis
  • female
  • human
  • Human immunodeficiency virus infected patient
  • Human immunodeficiency virus infection
  • Italy
  • major clinical study
  • male
  • multicenter study
  • observational study
  • prospective study
  • retention in care
  • therapy delay
  • time
  • time to treatment
  • treatment response

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