Virological response to salvage therapy in HIV-infected persons carrying the reverse transcriptase K65R mutation

Andrea Antinori, Maria Paola Trotta, Patrizia Lorenzini, Carlo Torti, Nicola Gianotti, Franco Maggiolo, Francesca Ceccherini-Silberstein, Paola Nasta, Antonella Castagna, Andrea De Luca, Cristina Mussini, Massimo Andreoni, Carlo Federico Perno

Research output: Contribution to journalArticle

Abstract

Background: The effect of the HIV reverse transcriptase K65R mutation on virological response to salvage therapy has not been clearly defined. Methods: From six Italian clinical centres, all consecutive patients starting salvage antiretroviral therapy after virological failure in the presence of the K65R mutation identified by a genotypic resistance test were selected. Results: Among 145 subjects included over a 197 person-year follow-up, the estimated probability of virological response (VR, defined as reaching HIV RNA 10 copies/ml (interquartile range [IQR] 0.10-2.46): at multivariable regression analysis, salvage regimens containing a TA (β=+0.80; P=0.02) and lamivudine (β=+1.21; P=0.02) as new drug had a positive effect on the reduction of HIV-1 RNA. Conclusions: Development of the K65R mutation does not preclude a high rate of virological response to rescue therapy. Inclusion of a TA in the salvage regimen and the presence of a M184V mutation could have a favourable effect on virological outcome.

Original languageEnglish
Pages (from-to)1175-1183
Number of pages9
JournalAntiviral Therapy
Volume12
Issue number8
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Pharmacology

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    Antinori, A., Trotta, M. P., Lorenzini, P., Torti, C., Gianotti, N., Maggiolo, F., Ceccherini-Silberstein, F., Nasta, P., Castagna, A., De Luca, A., Mussini, C., Andreoni, M., & Perno, C. F. (2007). Virological response to salvage therapy in HIV-infected persons carrying the reverse transcriptase K65R mutation. Antiviral Therapy, 12(8), 1175-1183.