Virtual Morris task responses in individuals in an abstinence phase from alcohol

Mauro Ceccanti, Giovanna Coriale, Derek A Hamilton, Valentina Carito, Roberto Coccurello, Bruna Scalese, Stefania Ciafrè, Claudia Codazzo, Marisa Patrizia Messina, George N Chaldakov, Marco Fiore

Research output: Contribution to journalArticle

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Abstract

The present study was aimed at examining spatial learning and memory, in 33 men and 12 women with alcohol use disorder (AUD) undergoing ethanol detoxification, by using a virtual Morris task. As controls, we recruited 29 men and 10 women among episodic drinkers without a history of alcohol addiction or alcohol-related diseases. Elevated latency to the first movement in all trials was observed only in AUD persons; furthermore, control women had longer latencies compared with control men. Increased time spent to reach the hidden platform in the learning phase was found for women of both groups compared with men, in particular during trial 3. As predicted, AUD persons (more evident in men) spent less time in the target quadrant during the probe trial; however, AUD women had longer latencies to reach the platform in the visible condition during trials 6 and 7 that resulted in a greater distance moved. As for the probe trial, men of both groups showed increased virtual locomotion compared with the women of both groups. The present investigation confirms and extends previous studies showing (i) different gender responses in spatial learning tasks, (ii) some alterations due to alcohol addiction in virtual spatial learning, and (iii) differences between AUD men and AUD women in spatial-behaviour-related paradigms.

Original languageEnglish
Pages (from-to)128-136
Number of pages9
JournalCanadian Journal of Physiology and Pharmacology
Volume96
Issue number2
DOIs
Publication statusE-pub ahead of print - Aug 1 2017

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Alcohol Abstinence
Alcohols
Alcoholism
Spatial Behavior
Locomotion
Ethanol
Learning

Keywords

  • Journal Article

Cite this

Virtual Morris task responses in individuals in an abstinence phase from alcohol. / Ceccanti, Mauro; Coriale, Giovanna; Hamilton, Derek A; Carito, Valentina; Coccurello, Roberto; Scalese, Bruna; Ciafrè, Stefania; Codazzo, Claudia; Messina, Marisa Patrizia; Chaldakov, George N; Fiore, Marco.

In: Canadian Journal of Physiology and Pharmacology, Vol. 96, No. 2, 01.08.2017, p. 128-136.

Research output: Contribution to journalArticle

Ceccanti, M, Coriale, G, Hamilton, DA, Carito, V, Coccurello, R, Scalese, B, Ciafrè, S, Codazzo, C, Messina, MP, Chaldakov, GN & Fiore, M 2017, 'Virtual Morris task responses in individuals in an abstinence phase from alcohol', Canadian Journal of Physiology and Pharmacology, vol. 96, no. 2, pp. 128-136. https://doi.org/10.1139/cjpp-2017-0013
Ceccanti, Mauro ; Coriale, Giovanna ; Hamilton, Derek A ; Carito, Valentina ; Coccurello, Roberto ; Scalese, Bruna ; Ciafrè, Stefania ; Codazzo, Claudia ; Messina, Marisa Patrizia ; Chaldakov, George N ; Fiore, Marco. / Virtual Morris task responses in individuals in an abstinence phase from alcohol. In: Canadian Journal of Physiology and Pharmacology. 2017 ; Vol. 96, No. 2. pp. 128-136.
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