Virtual screening approach for the identification of new Rac1 inhibitors

Nicola Ferri, Alberto Corsini, Paolo Bottino, Francesca Clerici, Alessandro Contini

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Abstract

Rac1 protein is implicated in several events of atherosclerotic plaque development and represents a new potential pharmacological target for cardiovascular diseases. In this paper we describe a pharmacophore virtual screening followed by molecular docking calculations leading to the identification of five new Rac1 inhibitors. These compounds were shown to be more effective than the reference compound NSC23766 in reducing the intracellular levels of Rac1-GTP, thus supporting this approach for the development of new Rac1 inhibitors.

Original languageEnglish
Pages (from-to)4087-4090
Number of pages4
JournalJournal of Medicinal Chemistry
Volume52
Issue number14
DOIs
Publication statusPublished - Jul 23 2009

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ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Ferri, N., Corsini, A., Bottino, P., Clerici, F., & Contini, A. (2009). Virtual screening approach for the identification of new Rac1 inhibitors. Journal of Medicinal Chemistry, 52(14), 4087-4090. https://doi.org/10.1021/jm8015987