Visceral fat is associated with cardiovascular risk in women with polycystic ovary syndrome

Teresa Cascella, Stefano Palomba, Ilario De Sio, Francesco Manguso, Francesco Giallauria, Biagio De Simone, Domenico Tafuri, Gaetano Lombardi, Annamaria Colao, Francesco Orio

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Women with polycystic ovary syndrome (PCOS) have been reported to have subclinical cardiovascular disease (CVD) and increased abdominal fat. The aim of this study was to evaluate the relationship between visceral fat (VF) and early markers of CVD in PCOS women. METHODS: Two hundred overweight PCOS women [(mean ± SD) age 24.6 ± 3.2 years, body mass index (BMI) 28.5 ± 2.8 kg/m2] and 100 healthy age- and BMI-matched volunteer controls entered this cross-sectional study. In all subjects, the amount of VF was measured by ultrasonography. Anthropometric measurements [BMI and waist circumference (WC)], complete hormonal and metabolic pattern, carotid intima-media thickness (IMT), brachial arterial flow-mediated dilation (FMD) and inflammatory biomarkers [C-reactive protein (CRP), fibrinogen, white blood cells count and plasminogen activated inhibitor-1] were also obtained from all subjects. A stepwise linear regression model was used in PCOS patients to verify if IMT or FMD as dependent variables are affected by other independent variables. RESULTS: VF amount was significantly (P <0.001) higher in PCOS subjects than in healthy controls [31.4 ± 7.3 versus 28.0 ± 6.1 (mean±SD) mm, respectively] and directly related to insulin resistance: HOMA (r = 0.918, P <0.001) and AUCINS (r = 0.879, P <0.001), and to WC (r = 0.658; P <0.001). In PCOS, the two linear regression analyses showed that IMT is positively affected by VF and CRP, whereas FMD is positively affected by IMT and negatively by VF and CRP. CONCLUSIONS: VF amount is associated with subclinical CVD in PCOS patients.

Original languageEnglish
Pages (from-to)153-159
Number of pages7
JournalHuman Reproduction
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 2008

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Intra-Abdominal Fat
Polycystic Ovary Syndrome
C-Reactive Protein
Dilatation
Linear Models
Body Mass Index
Cardiovascular Diseases
Waist Circumference
Abdominal Fat
Carotid Intima-Media Thickness
Plasminogen
Leukocyte Count
Fibrinogen
Insulin Resistance
Volunteers
Ultrasonography
Healthy Volunteers
Arm
Cross-Sectional Studies
Biomarkers

Keywords

  • Cardiovascular risk
  • Hyperandrogenism
  • Insulin resistance
  • PCOS
  • Visceral fat

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Medicine(all)

Cite this

Cascella, T., Palomba, S., De Sio, I., Manguso, F., Giallauria, F., De Simone, B., ... Orio, F. (2008). Visceral fat is associated with cardiovascular risk in women with polycystic ovary syndrome. Human Reproduction, 23(1), 153-159. https://doi.org/10.1093/humrep/dem356

Visceral fat is associated with cardiovascular risk in women with polycystic ovary syndrome. / Cascella, Teresa; Palomba, Stefano; De Sio, Ilario; Manguso, Francesco; Giallauria, Francesco; De Simone, Biagio; Tafuri, Domenico; Lombardi, Gaetano; Colao, Annamaria; Orio, Francesco.

In: Human Reproduction, Vol. 23, No. 1, 01.2008, p. 153-159.

Research output: Contribution to journalArticle

Cascella, T, Palomba, S, De Sio, I, Manguso, F, Giallauria, F, De Simone, B, Tafuri, D, Lombardi, G, Colao, A & Orio, F 2008, 'Visceral fat is associated with cardiovascular risk in women with polycystic ovary syndrome', Human Reproduction, vol. 23, no. 1, pp. 153-159. https://doi.org/10.1093/humrep/dem356
Cascella T, Palomba S, De Sio I, Manguso F, Giallauria F, De Simone B et al. Visceral fat is associated with cardiovascular risk in women with polycystic ovary syndrome. Human Reproduction. 2008 Jan;23(1):153-159. https://doi.org/10.1093/humrep/dem356
Cascella, Teresa ; Palomba, Stefano ; De Sio, Ilario ; Manguso, Francesco ; Giallauria, Francesco ; De Simone, Biagio ; Tafuri, Domenico ; Lombardi, Gaetano ; Colao, Annamaria ; Orio, Francesco. / Visceral fat is associated with cardiovascular risk in women with polycystic ovary syndrome. In: Human Reproduction. 2008 ; Vol. 23, No. 1. pp. 153-159.
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AU - Cascella, Teresa

AU - Palomba, Stefano

AU - De Sio, Ilario

AU - Manguso, Francesco

AU - Giallauria, Francesco

AU - De Simone, Biagio

AU - Tafuri, Domenico

AU - Lombardi, Gaetano

AU - Colao, Annamaria

AU - Orio, Francesco

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N2 - BACKGROUND: Women with polycystic ovary syndrome (PCOS) have been reported to have subclinical cardiovascular disease (CVD) and increased abdominal fat. The aim of this study was to evaluate the relationship between visceral fat (VF) and early markers of CVD in PCOS women. METHODS: Two hundred overweight PCOS women [(mean ± SD) age 24.6 ± 3.2 years, body mass index (BMI) 28.5 ± 2.8 kg/m2] and 100 healthy age- and BMI-matched volunteer controls entered this cross-sectional study. In all subjects, the amount of VF was measured by ultrasonography. Anthropometric measurements [BMI and waist circumference (WC)], complete hormonal and metabolic pattern, carotid intima-media thickness (IMT), brachial arterial flow-mediated dilation (FMD) and inflammatory biomarkers [C-reactive protein (CRP), fibrinogen, white blood cells count and plasminogen activated inhibitor-1] were also obtained from all subjects. A stepwise linear regression model was used in PCOS patients to verify if IMT or FMD as dependent variables are affected by other independent variables. RESULTS: VF amount was significantly (P <0.001) higher in PCOS subjects than in healthy controls [31.4 ± 7.3 versus 28.0 ± 6.1 (mean±SD) mm, respectively] and directly related to insulin resistance: HOMA (r = 0.918, P <0.001) and AUCINS (r = 0.879, P <0.001), and to WC (r = 0.658; P <0.001). In PCOS, the two linear regression analyses showed that IMT is positively affected by VF and CRP, whereas FMD is positively affected by IMT and negatively by VF and CRP. CONCLUSIONS: VF amount is associated with subclinical CVD in PCOS patients.

AB - BACKGROUND: Women with polycystic ovary syndrome (PCOS) have been reported to have subclinical cardiovascular disease (CVD) and increased abdominal fat. The aim of this study was to evaluate the relationship between visceral fat (VF) and early markers of CVD in PCOS women. METHODS: Two hundred overweight PCOS women [(mean ± SD) age 24.6 ± 3.2 years, body mass index (BMI) 28.5 ± 2.8 kg/m2] and 100 healthy age- and BMI-matched volunteer controls entered this cross-sectional study. In all subjects, the amount of VF was measured by ultrasonography. Anthropometric measurements [BMI and waist circumference (WC)], complete hormonal and metabolic pattern, carotid intima-media thickness (IMT), brachial arterial flow-mediated dilation (FMD) and inflammatory biomarkers [C-reactive protein (CRP), fibrinogen, white blood cells count and plasminogen activated inhibitor-1] were also obtained from all subjects. A stepwise linear regression model was used in PCOS patients to verify if IMT or FMD as dependent variables are affected by other independent variables. RESULTS: VF amount was significantly (P <0.001) higher in PCOS subjects than in healthy controls [31.4 ± 7.3 versus 28.0 ± 6.1 (mean±SD) mm, respectively] and directly related to insulin resistance: HOMA (r = 0.918, P <0.001) and AUCINS (r = 0.879, P <0.001), and to WC (r = 0.658; P <0.001). In PCOS, the two linear regression analyses showed that IMT is positively affected by VF and CRP, whereas FMD is positively affected by IMT and negatively by VF and CRP. CONCLUSIONS: VF amount is associated with subclinical CVD in PCOS patients.

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KW - Hyperandrogenism

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KW - PCOS

KW - Visceral fat

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