Visceral leishmaniasis revealing chronic granulomatous diseases in a child

A. Finocchi, Paolo Palma, G. Di Matteo, M. Chiriaco, L. Lancella, A. Simonetti, I. Rana, S. Livadiotti, P. Rossi

Research output: Contribution to journalArticle

Abstract

We report the first description of visceral leishmaniasis (VL) infection as a harbinger of chronic granulomatous disease (CGD) in a 3-year old child. Although VL is not frequently suspected in CGD patients, our case emphasises the importance of a complete evaluation of the immune system in children presenting with VL in order to exclude underlying immunodeficiency states. As the prognosis of CGD is poor, with high morbidity and mortality, establishing an early diagnosis has important practical implications in the successful treatment of these patients. Following the diagnosis, the patient received Human Leukocyte Antigen (HLA) identical sibling bone marrow transplantation (BMT). The child is now 2 years post-transplant and is in good general conditions with normal blood counts, and evidence of full-donor chimerism in repeated fluorescence in situ hybridization (FISH) studies.

Original languageEnglish
Pages (from-to)739-743
Number of pages5
JournalInternational Journal of Immunopathology and Pharmacology
Volume21
Issue number3
Publication statusPublished - Jul 2008

Fingerprint

Chronic Granulomatous Disease
Visceral Leishmaniasis
Chimerism
HLA Antigens
Fluorescence In Situ Hybridization
Bone Marrow Transplantation
Siblings
Early Diagnosis
Immune System
Tissue Donors
Morbidity
Transplants
Mortality
Infection
Therapeutics

Keywords

  • Bone marrow transplant
  • Children
  • Chronic granulomatous disease
  • Immunodeficiency
  • Visceral leishmaniasis

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

Cite this

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title = "Visceral leishmaniasis revealing chronic granulomatous diseases in a child",
abstract = "We report the first description of visceral leishmaniasis (VL) infection as a harbinger of chronic granulomatous disease (CGD) in a 3-year old child. Although VL is not frequently suspected in CGD patients, our case emphasises the importance of a complete evaluation of the immune system in children presenting with VL in order to exclude underlying immunodeficiency states. As the prognosis of CGD is poor, with high morbidity and mortality, establishing an early diagnosis has important practical implications in the successful treatment of these patients. Following the diagnosis, the patient received Human Leukocyte Antigen (HLA) identical sibling bone marrow transplantation (BMT). The child is now 2 years post-transplant and is in good general conditions with normal blood counts, and evidence of full-donor chimerism in repeated fluorescence in situ hybridization (FISH) studies.",
keywords = "Bone marrow transplant, Children, Chronic granulomatous disease, Immunodeficiency, Visceral leishmaniasis",
author = "A. Finocchi and Paolo Palma and {Di Matteo}, G. and M. Chiriaco and L. Lancella and A. Simonetti and I. Rana and S. Livadiotti and P. Rossi",
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AU - Finocchi, A.

AU - Palma, Paolo

AU - Di Matteo, G.

AU - Chiriaco, M.

AU - Lancella, L.

AU - Simonetti, A.

AU - Rana, I.

AU - Livadiotti, S.

AU - Rossi, P.

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N2 - We report the first description of visceral leishmaniasis (VL) infection as a harbinger of chronic granulomatous disease (CGD) in a 3-year old child. Although VL is not frequently suspected in CGD patients, our case emphasises the importance of a complete evaluation of the immune system in children presenting with VL in order to exclude underlying immunodeficiency states. As the prognosis of CGD is poor, with high morbidity and mortality, establishing an early diagnosis has important practical implications in the successful treatment of these patients. Following the diagnosis, the patient received Human Leukocyte Antigen (HLA) identical sibling bone marrow transplantation (BMT). The child is now 2 years post-transplant and is in good general conditions with normal blood counts, and evidence of full-donor chimerism in repeated fluorescence in situ hybridization (FISH) studies.

AB - We report the first description of visceral leishmaniasis (VL) infection as a harbinger of chronic granulomatous disease (CGD) in a 3-year old child. Although VL is not frequently suspected in CGD patients, our case emphasises the importance of a complete evaluation of the immune system in children presenting with VL in order to exclude underlying immunodeficiency states. As the prognosis of CGD is poor, with high morbidity and mortality, establishing an early diagnosis has important practical implications in the successful treatment of these patients. Following the diagnosis, the patient received Human Leukocyte Antigen (HLA) identical sibling bone marrow transplantation (BMT). The child is now 2 years post-transplant and is in good general conditions with normal blood counts, and evidence of full-donor chimerism in repeated fluorescence in situ hybridization (FISH) studies.

KW - Bone marrow transplant

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KW - Chronic granulomatous disease

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KW - Visceral leishmaniasis

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