Abstract
Cultures of limbal cells are a safe and effective treatment for the destruction of the human cornea owing to chemical burns. The essential feature of the graft is the presence of an adequate number of stem cells, which can be determined by the expression of the p63 transcription factor. Here, we will discuss the general principles defining the rigorous criteria for graftable limbal cultures in light of their clinical performances. Such criteria might prove relevant to the future therapeutic use of any cultured cell type.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Trends in Molecular Medicine |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2011 |
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ASJC Scopus subject areas
- Molecular Biology
- Molecular Medicine
- Medicine(all)
Cite this
Vision from the right stem. / Pellegrini, Graziella; Rama, Paolo; De Luca, Michele.
In: Trends in Molecular Medicine, Vol. 17, No. 1, 01.2011, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vision from the right stem
AU - Pellegrini, Graziella
AU - Rama, Paolo
AU - De Luca, Michele
PY - 2011/1
Y1 - 2011/1
N2 - Cultures of limbal cells are a safe and effective treatment for the destruction of the human cornea owing to chemical burns. The essential feature of the graft is the presence of an adequate number of stem cells, which can be determined by the expression of the p63 transcription factor. Here, we will discuss the general principles defining the rigorous criteria for graftable limbal cultures in light of their clinical performances. Such criteria might prove relevant to the future therapeutic use of any cultured cell type.
AB - Cultures of limbal cells are a safe and effective treatment for the destruction of the human cornea owing to chemical burns. The essential feature of the graft is the presence of an adequate number of stem cells, which can be determined by the expression of the p63 transcription factor. Here, we will discuss the general principles defining the rigorous criteria for graftable limbal cultures in light of their clinical performances. Such criteria might prove relevant to the future therapeutic use of any cultured cell type.
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UR - http://www.scopus.com/inward/citedby.url?scp=78650967381&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2010.10.003
DO - 10.1016/j.molmed.2010.10.003
M3 - Article
C2 - 21075055
AN - SCOPUS:78650967381
VL - 17
SP - 1
EP - 7
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
SN - 1471-4914
IS - 1
ER -