Abstract

To evaluate the change over time of vision-related quality of life (QoL) and glaucoma symptoms in a population of newly-diagnosed primary open angle glaucoma (POAG) patients. Multicenter, prospective study. Consecutive newly-diagnosed POAG patients were enrolled and followed-up for one year. Follow-up visits were scheduled at 6 and 12 months from baseline. At each visit, vision-related QoL and glaucoma-related symptoms were assessed by the means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the Glaucoma Symptom Scale (GSS), respectively. Trends over time for NEI-VFQ-25 and GSS scores were evaluated with longitudinal linear mixed models. One-hundred seventy-eight patients were included in the analysis. At baseline, early to moderate glaucoma stages were associated with higher scores for most GSS and NEI-VFQ-25 items, while lower best-corrected visual acuity was associated with lower scores for 4 of the 12 NEI-VFQ-25 items. During the follow-up, all the GSS scores, the NEI-VFQ-25 total score, and 7 of the 12 NEI-VFQ-25 scores significantly improved (p < 0.05). In multivariate model, higher increases of most GSS and NEI-VFQ-25 scores were modeled in patients with low scores at baseline. Vision-related QoL and glaucoma-related symptom perception significantly improved during the one-year follow-up in this population of newly diagnosed POAG patients.

Original languageEnglish
Article number6735
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 1 2019

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Glaucoma
Quality of Life
National Eye Institute (U.S.)
Primary Open Angle Glaucoma
Population
Visual Acuity
Multicenter Studies
Linear Models
Prospective Studies

ASJC Scopus subject areas

  • General

Cite this

Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients. / The Italian Study Group on QoL in Glaucoma.

In: Scientific Reports, Vol. 9, No. 1, 6735, 01.12.2019.

Research output: Contribution to journalArticle

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abstract = "To evaluate the change over time of vision-related quality of life (QoL) and glaucoma symptoms in a population of newly-diagnosed primary open angle glaucoma (POAG) patients. Multicenter, prospective study. Consecutive newly-diagnosed POAG patients were enrolled and followed-up for one year. Follow-up visits were scheduled at 6 and 12 months from baseline. At each visit, vision-related QoL and glaucoma-related symptoms were assessed by the means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the Glaucoma Symptom Scale (GSS), respectively. Trends over time for NEI-VFQ-25 and GSS scores were evaluated with longitudinal linear mixed models. One-hundred seventy-eight patients were included in the analysis. At baseline, early to moderate glaucoma stages were associated with higher scores for most GSS and NEI-VFQ-25 items, while lower best-corrected visual acuity was associated with lower scores for 4 of the 12 NEI-VFQ-25 items. During the follow-up, all the GSS scores, the NEI-VFQ-25 total score, and 7 of the 12 NEI-VFQ-25 scores significantly improved (p < 0.05). In multivariate model, higher increases of most GSS and NEI-VFQ-25 scores were modeled in patients with low scores at baseline. Vision-related QoL and glaucoma-related symptom perception significantly improved during the one-year follow-up in this population of newly diagnosed POAG patients.",
author = "{The Italian Study Group on QoL in Glaucoma} and Ivano Riva and Lorenzo Legramandi and Eliana Rulli and Konstas, {Anastasios G.} and Andreas Katsanos and Francesco Oddone and Weinreb, {Robert N.} and Luciano Quaranta and L. Varano and T. Carchedi and S. Talarico and F. Parravano and I. Motolese and Bagaglia, {S. A.} and Rossi, {G. C.M.} and S. Lateri and L. Bossolesi and L. Carmassi and T. Rolle and R. Piccini and R. Ratiglia and A. Rossi and S. Gandolfi and Tagliavini and N. Ungaro and M. Fossarello and A. Cuccu and I. Zucca and M. Uva and E. Bonacci and G. Cardarella and D. Tognetto and O. Vattovani and P. Vallon and F. Iannacone and L. Fontana and S. Marchi and Manni, {G. L.} and D. Jannetta and G. Roberti and L. Rossetti and E. Maggiolo and O. Oneta and C. Sborgia and F. Cantatore and L. Mastropasqua and L. Agnifili and E. Campos and M. Cassamali and C. Traverso",
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AU - The Italian Study Group on QoL in Glaucoma

AU - Riva, Ivano

AU - Legramandi, Lorenzo

AU - Rulli, Eliana

AU - Konstas, Anastasios G.

AU - Katsanos, Andreas

AU - Oddone, Francesco

AU - Weinreb, Robert N.

AU - Quaranta, Luciano

AU - Varano, L.

AU - Carchedi, T.

AU - Talarico, S.

AU - Parravano, F.

AU - Motolese, I.

AU - Bagaglia, S. A.

AU - Rossi, G. C.M.

AU - Lateri, S.

AU - Bossolesi, L.

AU - Carmassi, L.

AU - Rolle, T.

AU - Piccini, R.

AU - Ratiglia, R.

AU - Rossi, A.

AU - Gandolfi, S.

AU - Tagliavini,

AU - Ungaro, N.

AU - Fossarello, M.

AU - Cuccu, A.

AU - Zucca, I.

AU - Uva, M.

AU - Bonacci, E.

AU - Cardarella, G.

AU - Tognetto, D.

AU - Vattovani, O.

AU - Vallon, P.

AU - Iannacone, F.

AU - Fontana, L.

AU - Marchi, S.

AU - Manni, G. L.

AU - Jannetta, D.

AU - Roberti, G.

AU - Rossetti, L.

AU - Maggiolo, E.

AU - Oneta, O.

AU - Sborgia, C.

AU - Cantatore, F.

AU - Mastropasqua, L.

AU - Agnifili, L.

AU - Campos, E.

AU - Cassamali, M.

AU - Traverso, C.

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N2 - To evaluate the change over time of vision-related quality of life (QoL) and glaucoma symptoms in a population of newly-diagnosed primary open angle glaucoma (POAG) patients. Multicenter, prospective study. Consecutive newly-diagnosed POAG patients were enrolled and followed-up for one year. Follow-up visits were scheduled at 6 and 12 months from baseline. At each visit, vision-related QoL and glaucoma-related symptoms were assessed by the means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the Glaucoma Symptom Scale (GSS), respectively. Trends over time for NEI-VFQ-25 and GSS scores were evaluated with longitudinal linear mixed models. One-hundred seventy-eight patients were included in the analysis. At baseline, early to moderate glaucoma stages were associated with higher scores for most GSS and NEI-VFQ-25 items, while lower best-corrected visual acuity was associated with lower scores for 4 of the 12 NEI-VFQ-25 items. During the follow-up, all the GSS scores, the NEI-VFQ-25 total score, and 7 of the 12 NEI-VFQ-25 scores significantly improved (p < 0.05). In multivariate model, higher increases of most GSS and NEI-VFQ-25 scores were modeled in patients with low scores at baseline. Vision-related QoL and glaucoma-related symptom perception significantly improved during the one-year follow-up in this population of newly diagnosed POAG patients.

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