Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients

The Italian Study Group on QoL in Glaucoma, Ivano Riva, Lorenzo Legramandi, Eliana Rulli, Anastasios G. Konstas, Andreas Katsanos, Francesco Oddone, Robert N. Weinreb, Luciano Quaranta, L. Varano, T. Carchedi, S. Talarico, F. Parravano, I. Motolese, S. A. Bagaglia, G. C.M. Rossi, S. Lateri, L. Bossolesi, L. Carmassi, T. RolleR. Piccini, R. Ratiglia, A. Rossi, S. Gandolfi, Tagliavini [Unknown], N. Ungaro, M. Fossarello, A. Cuccu, I. Zucca, M. Uva, E. Bonacci, G. Cardarella, D. Tognetto, O. Vattovani, P. Vallon, F. Iannacone, L. Fontana, S. Marchi, G. L. Manni, D. Jannetta, G. Roberti, L. Rossetti, E. Maggiolo, O. Oneta, C. Sborgia, F. Cantatore, L. Mastropasqua, L. Agnifili, E. Campos, M. Cassamali, C. Traverso

Research output: Contribution to journalArticlepeer-review


To evaluate the change over time of vision-related quality of life (QoL) and glaucoma symptoms in a population of newly-diagnosed primary open angle glaucoma (POAG) patients. Multicenter, prospective study. Consecutive newly-diagnosed POAG patients were enrolled and followed-up for one year. Follow-up visits were scheduled at 6 and 12 months from baseline. At each visit, vision-related QoL and glaucoma-related symptoms were assessed by the means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the Glaucoma Symptom Scale (GSS), respectively. Trends over time for NEI-VFQ-25 and GSS scores were evaluated with longitudinal linear mixed models. One-hundred seventy-eight patients were included in the analysis. At baseline, early to moderate glaucoma stages were associated with higher scores for most GSS and NEI-VFQ-25 items, while lower best-corrected visual acuity was associated with lower scores for 4 of the 12 NEI-VFQ-25 items. During the follow-up, all the GSS scores, the NEI-VFQ-25 total score, and 7 of the 12 NEI-VFQ-25 scores significantly improved (p <0.05). In multivariate model, higher increases of most GSS and NEI-VFQ-25 scores were modeled in patients with low scores at baseline. Vision-related QoL and glaucoma-related symptom perception significantly improved during the one-year follow-up in this population of newly diagnosed POAG patients.
Original languageEnglish
JournalSci. Rep.
Issue number1
Publication statusPublished - Dec 1 2019


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